Prognostic value of platelet-derived growth factor-A (PDGF-A) in gastric carcinoma
Prognostic value of platelet-derived growth factor-A (PDGF-A) in gastric carcinoma
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DOI：
10.1097/00000658-199803000-00008
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发表时间：
1998-03-01
影响因子：
9
通讯作者：
Morisaki, T
中科院分区：
文献类型：
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作者：
Katano, M;Nakamura, M;Morisaki, T
目的鉴于我们先前的研究表明，胃癌活检标本中血小板衍生生长因子-A(PDGF-A)基因的表达可作为判断胃癌高危人群的指标，本研究分析了胃癌活检标本中血小板衍生生长因子-A(PDGF-A)基因表达的预后价值。方法采用逆转录-聚合酶链式反应(RT-PCR)方法检测65例胃癌活检标本中PDGF-A基因的表达。将65例患者分为PDGFA阳性组(29例)和阴性组(36例)。结果2年随访资料显示，阳性组总生存率低于阴性组(P<0.0001)。在34名晚期患者(p=0.003)和24名接受根治性切除的晚期患者(p=0.003)中发现了类似的相关性。多变量分析显示，PDGF-A基因的转录是一个独立于传统病理参数的有效预后因素。结论胃活检组织中PDGF-A基因的表达可能是一项新的术前预后指标。
ObjectiveBecause our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specimens.MethodsReverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyze the PDGF-A gene expression in 65 gastric carcinoma endoscopic biopsy specimens. The 65 patients were divided into a PDGF-A-positive group (29 patients) and a PDGF-A-negative group (36 patients).ResultsOn the basis of 2-year follow-up data, the PDGF-A-positive group demonstrated a shorter overall survival rate compared with the PDGF-A-negative group (p < 0.0001). A similar correlation was found in 34 advanced-stage patients (p = 0.003) and in 24 advanced-stage patients who underwent a curative resection (p = 0.003). Multivariance analysis indicated that the transcription of PDGF-A gene is a potent prognostic factor that is independent of the traditional pathologic parameters.ConclusionsExpression of PDGF-A mRNA in gastric biopsy specimens may be a new preoperative prognostic parameter in gastric carcinoma.