Peritoneal ventilation with oxygen improves outcome after hemorrhagic shock in rats
Peritoneal ventilation with oxygen improves outcome after hemorrhagic shock in rats
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DOI：
10.1097/00003246-200012000-00027
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发表时间：
2000-12-01
影响因子：
8.8
通讯作者：
Eshel, G
中科院分区：
文献类型：
--
作者：
Barr, J;Prueckner, S;Eshel, G
目的：在实验性低氧肺实变兔模型中，100%氧腹腔通气（PV-O-2）可改善Pao（2）。我们假设PV-O-2可以通过减轻腹部脏器的缺氧来改善肺正常的失血性休克（HS）后的结局。设计：随机、对照、实验室动物研究。设置：大学动物研究机构。主体：雄性Sprague-Dawley大鼠。干预措施：30只大鼠在轻度麻醉（N2 O/氧气加氟烷）和自主呼吸下进行了15分钟内3 mL/100 g的抽血。在60分钟的容量控制US阶段1之后，60分钟的复苏阶段2包括输注流出的血液，并且如果必要的话，静脉内补充乳酸林格氏溶液以控制60至120分钟的正常血压。随后是为期7天的第三观察阶段。我们随机分为三组，每组10只大鼠：第一组接受PV-O-2，从15分钟开始，以40次充气/分钟的速率，腹膜“潮气量”为6 mt，直到第二阶段结束。组II接受相同的室内空气PV（PV-Air）。对照组III在没有PV的情况下进行治疗。测量和主要结果：在US阶段1的后半部分期间，PV-O-2组I中的平均动脉压高于PV-Air组II和对照组III（p <0.05）。所有30只大鼠均在阶段1和阶段2的120分钟内存活，PV-O-2组I中10只大鼠中有10只存活至7天; PV-Air组II中10只大鼠中有9只存活至7天;对照组III中10只大鼠中有5只存活至7天（p <0.05 vs.组I; NS vs.组II）。生存时间
Objective: In experimental pulmonary consolidation with hypoxemia in rabbits, peritoneal ventilation (PV) with 100% oxygen (PV-O-2) improved Pao(2). We hypothesized that PV-O-2 could improve outcome after hemorrhagic shock (HS) with normal lungs, by mitigating dysoxia of the abdominal viscera,Design: Randomized, controlled, laboratory animal study.Setting: University animal research facility.Subjective: Male Sprague-Dawley rats.Interventions: Thirty rats under light anesthesia (N2O/oxygen plus halothane) and spontaneous breathing underwent blood withdrawal of 3 mL/100 g over 15 mins. After volume-controlled Us phase 1 of 60 mins, resuscitation phase 2 of 60 mins included infusion of shed blood and, if necessary, additional lactated Ringer's solution intravenously to control normotension from 60 to 120 mins. This was followed by observation phase 3 for 7 days. We randomized three groups of ten rats each: group I received PV-O-2, starting at 15 mins of Us at a rate of 40 inflations/min, and a peritoneal "tidal volume" of 6 mt, until the end of phase 2. Group II received the same PV with room air (PV-Air). Control group III was treated without PV.Measurements and Main Results: During the second half of Us phase 1, mean arterial pressures were higher in the PV-O-2 group I compared with the PV-Air group II and control group III (p < .05). All 30 rats survived the 120 mins of phases 1 and 2, survival to 7 days was achieved by ten of ten rats in PV-O-2 group I; by nine of ten in PV-Air group II; and by five of ten in control group III (p < .05 vs. group I; NS vs. group II). survival times of