Effects of green tea intake on the development of coronary artery disease
Effects of green tea intake on the development of coronary artery disease
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DOI：
10.1253/circj.68.665
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发表时间：
2004-07-01
影响因子：
3.3
通讯作者：
Mizuno, K
中科院分区：
文献类型：
--
作者：
Sano, J;Inami, S;Mizuno, K
研究背景绿色茶是日本的一种流行饮料，含有多种多酚类抗氧化剂，可预防动脉粥样硬化。本研究的目的是确定是否消费的绿色茶是proportionalassociated与冠状动脉疾病（CAD）和心脑血管预后的发病率降低。方法和结果研究组包括203例接受冠状动脉造影（109例患者有显着的冠状动脉狭窄和94例患者没有）。分析冠心病的预测因素，并随访患者的心脑血管事件。无CAD患者的绿色茶摄入量显著高于CAD患者（5.9 +/- 0.5 vs 3.5 +/- 0.3杯/天; p < 0.001）。绿色茶的摄入量与冠心病的发病率呈负相关（p < 0.001）。基于多变量logistic回归分析，每天摄入绿色茶是CAD的独立预测因子（比值比：0.84，95%置信区间：0.76-0.91）。相比之下，绿色茶的摄入量是不是一个预测的心血管和脑血管事件的考克斯比例风险model.Conclusions绿色茶的消费与CAD的发病率较低，在本研究的人群在日本。因此，患者饮用的绿色茶越多，患冠心病的可能性就越小。
Background Green tea, a popular beverage in Japan, contains many polyphenolic antioxidants, which might prevent atherosclerosis. This study was designed to determine whether the consumption of green tea is proportionately associated with a decreased incidence of coronary artery disease (CAD) and the cardiovascular and cerebrovascular prognosis.Methods and Results The study group comprised 203 patients who underwent coronary angiography (109 patients with significant coronary stenosis and 94 patients without). Predictors for CAD were analyzed and the patients' cardiovascular and cerebrovascular events were followed. Green tea consumption was significantly higher in patients without CAD than in those with CAD (5.9 +/- 0.5 vs 3.5 +/- 0.3 cups/day; p < 0.001). An inverse relationship between the intake of green tea and the incidence of CAD was observed (p < 0.001). The green tea intake per day was an independent predictor for CAD based on a multivariate logistic regression analysis (odds ratio: 0.84 and 95% confidence interval: 0.76-0.91). In contrast, the green tea intake was not a predictor of cardiovascular and cerebrovascular events based on the Cox proportional hazard model.Conclusions Green tea consumption was associated with a lower incidence of CAD in the present study population in Japan. Therefore, the more green tea patients consume, the less likely they are to have CAD.