Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications
Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications
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DOI：
10.1039/b907627c
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发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Hubbell, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Rothenfluh, Dominique A.;Hubbell, Jeffrey A.
聚合物纳米颗粒技术已经从药物载体设计发展到先进的多功能大分子结构。它们能够在时空控制下实现药物递送和生物活性物质的释放，而不仅仅是通过长循环载体的被动释放。因此，载体使生物分子或生物活性物质能够实现其设计的生物功能。由于其尺寸小，纳米颗粒也可能引起不同于任何其他生物材料的生物系统的扰动，因此开辟了新的生物医学应用，并引起了对不良反应的担忧。
Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.