Cardiac Purkinje fibers and arrhythmias; The GK Moe Award Lecture 2015.
Cardiac Purkinje fibers and arrhythmias; The GK Moe Award Lecture 2015.
复制标题
心脏Purkinje纤维和心律不齐； 2015年GK MOE奖演讲。
DOI：
10.1016/j.hrthm.2016.01.011
复制
发表时间：
2016-05
期刊：
影响因子：
5.5
通讯作者：
Robinson RB
中科院分区：
文献类型：
--
作者：
Boyden PA;Dun W;Robinson RB
浦肯野纤维/细胞仍然是心律失常学家关注的焦点。在这里，我们回顾了文献中出现的几个新想法，并将它们折叠成重要的新观点。这些要点包括浦肯野细胞中一些浦肯野特有的蛋白质、浦肯野细胞的起搏器功能可能与窦房结细胞相似、浦肯野纤维束/片的汇源问题、Ito 在心律失常和浦肯野遗传病变中的作用及其对心律的高度影响。尽管有关重塑浦肯野细胞的新想法不是本次综述的重点，但人们可以轻松想象浦肯野细胞及其功能在患病心脏中如何改变。
Purkinje fibers/cells continue to be a focus of arrhythmologists. Here we review several new ideas that have emerged in the literature and fold them into important new points. These points include some proteins in Purkinje cells that are specific to Purkinjes, pacemaker function in Purkinje may be similar to that of the sinus node cell, sink-source concerns about tracts/sheets of Purkinje fibers, role of Ito in arrhythmias and genetic lesions in Purkinjes and their high impact on cardiac rhythm. Although new ideas about the remodeled Purkinje cell are not the focus of this review, one can easily imagine how Purkinjes and their function may be altered in diseased hearts.