Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree.
Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree.
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DOI：
10.1038/srep45502
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发表时间：
2017-03-31
影响因子：
4.6
通讯作者：
Arisawa K
中科院分区：
文献类型：
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作者：
Uemura H;Ghaibeh AA;Katsuura-Kamano S;Yamaguchi M;Bahari T;Ishizu M;Moriguchi H;Arisawa K
为了研究日本人群中与2型糖尿病相关的未知模式，我们首先使用了交替决策树（ADTree）算法，这是一种来自数据挖掘的强大分类算法，用于1，102名年龄在35-69岁之间的受试者的数据。在调查模式的基础上，我们评估了作为全身炎症生物标志物的血清高敏C反应蛋白（hs-CRP）和糖尿病家族史（阴性、阳性或未知）与2型糖尿病患病率的关系，因为它们的详细关系很少报道。在调整可能的协变量后，包括体重指数和糖尿病家族史，血清hs-CRP水平升高与2型糖尿病患病率增加成比例相关（趋势P = 0.016）。分层分析显示，血清hs-CRP水平升高与无糖尿病家族史的受试者糖尿病患病率增加成比例相关（趋势P = 0.020），但与有糖尿病家族史或未知糖尿病家族史的受试者无关。我们的研究表明，全身炎症与2型糖尿病患病率的增加成比例相关，即使在调整体重指数后，特别是在没有糖尿病家族史的受试者中。
To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35–69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes (P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes (P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes.