Reduction of Influence of Task Difficulty on Perceptual Decision Making by STN Deep Brain Stimulation
Reduction of Influence of Task Difficulty on Perceptual Decision Making by STN Deep Brain Stimulation
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DOI：
10.1016/j.cub.2013.07.001
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发表时间：
2013-09-09
期刊：
影响因子：
9.2
通讯作者：
Heekeren, Hauke R.
中科院分区：
文献类型：
--
作者：
Green, Nikos;Bogacz, Rafal;Heekeren, Hauke R.
最佳决策的神经计算模型将一个关键角色-选择方案之间冲突的计算-归因于丘脑底核（ESTA）[1-3]。具体来说，这些模型预测，脑深部电刺激（DBS）的大脑皮层将减少决策冲突的影响。在这项工作中，帕金森病患者在打开和关闭DBS时判断随机点刺激的运动方向[4]。为了诱导决策冲突，我们改变了任务难度（运动连贯性），导致在健康受试者中具有更大任务难度的试验中反应时间（RT）增加。结果表明，DBS显着影响性能的知觉决策下的高决策冲突。RT大幅增加关DBS的任务变得更加困难，和扩散模型最好的行为数据。相比之下，在DBS，任务难度对RT的影响显着减少，种族模型最好地解释了观察到的数据。证据积累模型的个体数据拟合表明不同DBS状态下的信息处理不同。此外，与OFF DBS相比，ON DBS的速度-准确性权衡对决策标准调整幅度的影响显著较小。总之，这些研究结果表明，在高冲突的审判中，在感性决策的决策调整决策的关键作用。
Neurocomputational models of optimal decision making ascribe a crucial role-the computation of conflict between choice alternatives-to the subthalamic nucleus (STN) [1-3]. Specifically, these models predict that deep brain stimulation (DBS) of the STN will diminish the influence of decision conflict on decision making. In this work, patients with Parkinson's disease judged the direction of motion in random dot stimuli [4] while ON and OFF DBS. To induce decision conflict, we varied the task difficulty (motion coherence), leading to increased reaction time (RT) in trials with greater task difficulty in healthy subjects. Results indicate that DBS significantly influences performance for perceptual decisions under high decision conflict. RT increased substantially OFF DBS as the task became more difficult, and a diffusion model best accounted for behavioral data. In contrast, ON DBS, the influence of task difficulty on RT was significantly reduced and a race model best accounted for the observed data. Individual data fits of evidence accumulation models demonstrate different information processing under distinct DBS states. Furthermore, ON DBS, speed-accuracy tradeoffs affected the magnitude of decision criterion adjustment significantly less compared to OFF DBS. Together, these findings suggest a crucial role for the STN in adjusting decision making during high-conflict trials in perceptual decision making.