Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults
Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults
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DOI：
10.1007/s00421-012-2582-7
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发表时间：
2013-06-01
影响因子：
3
通讯作者：
Weaver, Lindell K.
中科院分区：
文献类型：
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作者：
Barker, Tyler;Martins, Thomas B.;Weaver, Lindell K.
本研究的目的是确定循环细胞因子，骨骼肌力量，峰值功率输出与对比血清25-羟基维生素D（25（OH）D）浓度的年轻人。因此，在年轻人（25-42岁）中测量血清25（OH）D、炎性细胞因子、肌肉力量和峰值功率输出。在冬季收集数据，以避免对血清25（OH）D的季节性影响。在血清25（OH）D浓度测量后，受试者被分为两组之一：（1）维生素D不足[血清25（OH）D <32 ng/mL，n = 14]或（2）维生素D充足[血清25（OH）D > 32 ng/mL，n = 14]。分组后，维生素D不足的成人血清25（OH）D浓度显著（p < 0.05）降低，促炎细胞因子[白细胞介素（IL）-2，IL-1 β，肿瘤坏死因子-α和干扰素-γ]显著（均p < 0.05）升高。抗炎细胞因子（即，IL-10; p > 0.05）、峰值等长力（p > 0.05）和峰值功率输出（p > 0.05）在维生素D组之间没有显著差异。然而，在维生素D不足的成年人中，峰值功率输出与血清25（OH）D浓度相关（r = 0.55，p < 0.05），但在维生素D充足的成年人中则不相关（r =-0.27，p = 0.36）。基于这些数据，我们得出结论，维生素D不足在一定程度上可能导致促炎性应激，而不会改变年轻人的肌肉力量或功能。未来的研究调查之间的因果关系低血清25（OH）D和峰值功率输出的年轻人是必要的。
The purpose of this study was to identify circulating cytokines, skeletal muscle strength, and peak power output in young adults with contrasting serum 25-hydroxyvitamin D (25(OH)D) concentrations. Serum 25(OH)D, inflammatory cytokines, muscle strength, and peak power output were, therefore, measured in young adults (25-42 years). Data were collected during the winter to avoid the seasonal influence on serum 25(OH)D. After serum 25(OH)D concentration measurements, subjects were separated into one of two groups: (1) vitamin D insufficient [serum 25(OH)D a parts per thousand currency sign32 ng/mL, n = 14], or (2) vitamin D sufficient [serum 25(OH)D > 32 ng/mL, n = 14]. Following group allocation, serum 25(OH)D concentrations were significantly (p < 0.05) lower and pro-inflammatory cytokines [interleukin (IL)-2, IL-1 beta, tumor necrosis factor-alpha, and interferon-gamma] were significantly (all p < 0.05) greater in vitamin D insufficient adults. An anti-inflammatory cytokine (i.e., IL-10; p > 0.05), peak isometric forces (p > 0.05), and peak power outputs (p > 0.05) were not significantly different between vitamin D groups. However, peak power outputs correlated with serum 25(OH)D concentrations in vitamin D insufficient (r = 0.55, p < 0.05) but not in vitamin D sufficient adults (r = -0.27, p = 0.36). Based on these data, we conclude that vitamin D insufficiency, in part, could result in pro-inflammatory stress without altering muscular strength or function in young adults. Future research investigating the causality of the correlation between low-serum 25(OH)D and peak power output in young adults is required.