LncRNA AB209630 inhibits gemcitabine resistance cell proliferation by regulating PI3K/AKT signaling in pancreatic ductal adenocarcinoma
LncRNA AB209630 inhibits gemcitabine resistance cell proliferation by regulating PI3K/AKT signaling in pancreatic ductal adenocarcinoma
复制标题
LncRNA AB209630 通过调节胰腺导管腺癌中的 PI3K/AKT 信号传导抑制吉西他滨耐药细胞增殖
DOI：
10.3233/cbm-181182
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Hua, Yong-Qiang
中科院分区：
文献类型：
--
作者：
Wang, Libin;Wang, Feng;Hua, Yong-Qiang
背景：最近的研究表明，长非编码RNA(lncRNAs，lncRNAs)的异常表达与胰腺癌化疗耐药有关。目的：本研究旨在探讨lncRNAAB209630的表达在胰腺癌吉西他滨耐药中的作用。方法：本研究中，lncRNAAB209630的高表达可抑制胰腺癌吉西他滨耐药细胞的增殖和集落形成能力。此外，Western印迹结果表明，LncRNA AB209630的上调抑制了吉西他滨耐药细胞中的PI3K/AKT信号通路。此外，我们还发现，与邻近正常组织相比，pDAC组织中lncRNA AB209630的表达显著下调。结论：lncRNA AB209630可能是PDAC治疗的潜在靶点。
BACKGROUND: Recent study revealed that abnormal long noncoding RNAs (lncRNAs) expression are association with chemotherapy resistance of pancreatic ductal adenocarcinoma (PDAC).OBJECTIVE: The present study was aimed to investigate the effects of lncRNA AB209630 expression for gemcitabine resistance in PDAC cells.METHODS: In the study, increased expression of lncRNA AB209630 could suppress cell proliferation and cell colony formation ability in gemcitabine resistance cells of PDAC. Furthermore, western blot results demonstrated that upregulation of lncRNA AB209630 suppressed the PI3K/AKT signaling pathway in gemcitabine resistance cells. Besides, we found that lncRNA AB209630 expression was dramatically downregulated in PDAC tissues compared to adjacent normal tissues. Lower PDAC expression predicted a poor prognosis in PDAC patients.CONCLUSIONS: Thus, these results indicated that lncRNA AB209630 may be a potential target of PDAC.