Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine
Neuroplasticity: A Key Player in the Antidepressant Action of Chinese Herbal Medicine
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神经可塑性：中草药抗抑郁作用的关键因素
DOI：
10.1142/s0192415x21500531
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发表时间：
2021
影响因子：
5.7
通讯作者：
Tao Weiwei
中科院分区：
文献类型：
--
作者：
Xia Baomei;Chen Chang;Tao Weiwei
中医学是一门系统医学。它以其临床经验、综合诊断和治疗理论为抑郁症的治疗提供了替代策略。中草药是中医方剂的主要形式，许多中草药已被证明具有显著的抗抑郁作用。多种机制与中药相关的抗抑郁特性有关。本文综述了中药抗抑郁作用的神经可塑性机制，发现中药通过改善神经发生、神经营养因子、突触棘形态、细胞信号传导、神经递质系统、单胺类神经递质和神经细胞凋亡来修复神经可塑性。因此，中药具有抗抑郁作用，试图为更好地理解中药抗抑郁作用的机制，为科学评价和发展中医药治疗抑郁症奠定基础。
Traditional Chinese medicine (TCM) is a systematic medicine. It provides alternative strategies for the treatment of depression with its clinical experience, comprehensive diagnosis, and treatment theory. Chinese herbal medicine (CHM) is the major form of TCM prescription, and numerous CHMs have been demonstrated to possess remarkable antidepressant-like properties. A diversity of mechanisms have been implicated in CHM-associated antidepressant property. This paper reviewed the neuroplastic mechanisms underlying the antidepressant actions of CHM, finding that CHM repairs neuroplasticity by improving neurogenesis, neurotrophic factors, synaptic spine morphology, cell signaling, glutamatergic system, monoamine neurotransmitters, and neural apoptosis. CHM thereby exerts an antidepressant effect, attempting to offer a better understanding of the mechanisms implicated in TCM-related antidepressant-like efficacy and laying a foundation for the scientific evaluation and development of TCM in treating depression.