A simple and efficient method for the facile access of highly functionalized pyridines and their fluorescence property studies
A simple and efficient method for the facile access of highly functionalized pyridines and their fluorescence property studies
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DOI：
10.1039/c2ra21385k
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发表时间：
2012-01-01
期刊：
影响因子：
3.9
通讯作者：
Choudhury, Lokman H.
中科院分区：
文献类型：
--
作者：
Khan, Md Nasim;Pal, Suman;Choudhury, Lokman H.
在本文中，我们描述了一种简单方便的方法，在催化量的Bronsted碱氢氧化钾存在下，醛、丙二腈和硫醇一锅多组分反应，有效地合成了高官能化的吡啶。该方法的显著特点是实验步骤简单，反应时间短，底物范围广，使用催化量易得且廉价的碱，产率高。用紫外-可见光谱和荧光光谱研究了合成的吡啶的光物理行为，发现部分合成的取代吡啶具有良好的荧光量子产率。
In this paper, we have described a simple and convenient method for the one-pot multicomponent reaction of aldehydes, malononitrile and thiols in the presence of a catalytic amount of Bronsted base potassium hydroxide for the efficient synthesis of highly functionalized pyridines. The notable features of this protocol are the simple experimental procedure, short reaction time, broad substrate scope and good yields using a catalytic amount of readily available and cheap base. The photophysical behaviours of the synthesized pyridines have been investigated by UV-Vis and fluorescence spectroscopy and some of the synthesized substituted pyridines exhibit promising fluorescence quantum yields.