Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria-mediated apoptosis
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria-mediated apoptosis
复制标题
单宁酸通过线粒体介导的细胞凋亡协同增强顺铂对肝癌细胞的抗癌功效
DOI：
10.3892/or.2019.7281
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发表时间：
2019-11-01
期刊：
影响因子：
4.2
通讯作者：
Chen, Jindong
中科院分区：
文献类型：
--
作者：
Geng, Nana;Zheng, Xiang;Chen, Jindong
顺铂（cis-dichlorodiamine platinum，CDDP）是一种有效的抗肿瘤药物。然而，其副作用和耐药性的发展限制了其临床应用。单宁酸（TA）以前曾被报道在不同类型的癌症中抑制肿瘤生长。本研究评价了TA联合CDDP对肝癌细胞系HepG 2的抗癌效果，并研究了相关的分子机制。结果显示，单独用TA或CDDP处理抑制HepG 2细胞生长，半最大抑制浓度分别为360 μ M和1.8 μ g/ml。TA和CDDP联合应用可诱导HepG 2细胞凋亡，与TA或CDDP单独应用相比，TA和CDDP联合应用可显著增强HepG 2细胞的生长抑制作用。本研究结果提示TA与CDDP联合应用可能具有协同抗肿瘤作用，可能成为肝癌的一种新的辅助治疗方法。
Cisplatin (cis-dichlorodiamine platinum, CDDP) is a potent antitumor agent. However, its clinical application is limited by its side effects and the development of drug resistance. Tannic acid (TA) has previously been reported to suppress tumor growth in different types of cancer. The present study evaluated the anticancer efficacy of TA in combination with CDDP on the liver cancer cell line HepG2, and investigated the associated underlying molecular mechanisms. The results revealed that treatment with TA or CDDP alone inhibited HepG2 cell growth, with a half maximal inhibitory concentration of 360 mu M and 1.8 mu g/ml, respectively. The combination of TA and CDDP induced mitochondria-mediated apoptosis in HepG2 cells and significantly enhanced the growth inhibitory effect compared with TA or CDDP treatment alone. The results obtained from the present study suggest that the combination of TA and CDDP may exert synergistic anticancer effects and may be a novel adjuvant treatment for liver cancer.