Effects of Fasting and Refeeding on Expression of Atrogin-1 and Akt/FOXO Signaling Pathway in Skeletal Muscle of Chicks
Effects of Fasting and Refeeding on Expression of Atrogin-1 and Akt/FOXO Signaling Pathway in Skeletal Muscle of Chicks
复制标题
禁食和复饲对雏鸡骨骼肌Atrogin-1和Akt/FOXO信号通路表达的影响
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
H. Abe
中科院分区：
文献类型：
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作者：
K. Nakashima;Y. Yakabe;M. Yamazaki;H. Abe
本实验旨在研究禁食和复饲对雏鸡骨骼肌中阿托金-1和Akt/FOXO信号通路表达的影响。将雏鸡禁食24 h后再饲喂2 h，禁食可增加Atrogin-1mRNA的表达，重新饲喂可降低Atrogin-1的表达。禁食不会降低Akt和FOXO1的磷酸化水平，但重新饲喂会增加它们的磷酸化水平。这些结果表明，再投喂刺激Akt/FOXO的磷酸化，导致雏鸡骨骼肌中阿托金-1的表达下降。
This experiment was conducted to study the effects of fasting and refeeding on expression of the atrogin-1 and Akt/FOXO signaling pathway in skeletal muscle of chicks. Chicks were fasted for 24 h and refed for 2 h. Atrogin-1 mRNA expression was increased by fasting, and their increment was reduced by refeeding. Phosphorylations of Akt and FOXO1 were not decreased by fasting, but, they were increased by refeeding. These results indicate that refeeding stimulates phosphorylation of Akt/FOXO, resulting in a decrease in atrogin-1 expression in skeletal muscle of chicks.
影响因子：
15.9
作者：
Price, SR;Bailey, JL;Mitch, WE
通讯作者：
Mitch, WE
影响因子：
37.8
作者：
Fujio, Y;Nguyen, T;Walsh, K
通讯作者：
Walsh, K