Plant immunity suppression via PHR1-RALF-FERONIA shapes the root microbiome to alleviate phosphate starvation
Plant immunity suppression via PHR1-RALF-FERONIA shapes the root microbiome to alleviate phosphate starvation
复制标题
通过 PHR1-RALF-FERONIA 抑制植物免疫，塑造根部微生物群，缓解磷酸盐饥饿
DOI：
10.15252/embj.2021109102
复制
发表时间：
2022-02-11
期刊：
影响因子：
11.4
通讯作者：
Yu, Feng
中科院分区：
文献类型：
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作者：
Tang, Jing;Wu, Dousheng;Yu, Feng
微生物组在塑造植物生长和免疫方面发挥着重要作用，但目前报道的影响植物微生物组组成的植物基因和通路却很少。在拟南芥中，近期研究发现，磷酸盐饥饿响应（PSR）在磷酸盐（Pi）饥饿时，会通过转录调节因子PHR1对根系微生物组进行调控。在此，我们报告称，拟南芥的PHR1可直接与快速碱化因子（RALF）基因的启动子结合，并在磷酸盐饥饿条件下激活其表达。反过来，RALF会通过FERONIA抑制病原体相关分子模式（PAMP）触发的免疫（PTI）受体的复合物形成，FERONIA是此前已确定的一种PTI调节剂，可增强植物对某些有害微生物的抗性。通过PHR1 - RALF - FERONIA轴对免疫的抑制，使得特定的根系微生物群能够定殖，这些微生物群可通过上调PSR基因的表达来缓解磷酸盐饥饿。这些发现为环境扰动后，通过调节植物先天免疫来协调宿主 - 微生物内稳态提供了一种新范式。
The microbiome plays an important role in shaping plant growth and immunity, but few plant genes and pathways impacting plant microbiome composition have been reported. In Arabidopsis thaliana, the phosphate starvation response (PSR) was recently found to modulate the root microbiome upon phosphate (Pi) starvation through the transcriptional regulator PHR1. Here, we report that A. thaliana PHR1 directly binds to the promoters of rapid alkalinization factor (RALF) genes, and activates their expression under phosphate-starvation conditions. RALFs in turn suppress complex formation of pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) receptor through FERONIA, a previously-identified PTI modulator that increases resistance to certain detrimental microorganisms. Suppression of immunity via the PHR1-RALF-FERONIA axis allows colonization by specialized root microbiota that help to alleviate phosphate starvation by upregulating the expression of PSR genes. These findings provide a new paradigm for coordination of host-microbe homeostasis through modulating plant innate immunity after environmental perturbations.