Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration.
Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration.
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多种后生动物寿命干预措施显示出初始死亡率与年龄依赖性死亡率加速之间存在性别特异性 Strehler-Mildvan 反比关系。
DOI：
10.1093/gerona/glw005
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Tower John
中科院分区：
文献类型：
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作者：
Shen Jie;L;is Gary N;Tower John
Gompertz方程以初始死亡率（参数 a），表明健康状况，死亡率随年龄而加速（参数B）， 显示出衰老对几项已发表研究的Gompertz参数进行了分析。在 雌性果蝇，交配增加了产卵量，缩短了平均寿命， 这与生殖和寿命之间的权衡是一致的。交配增加参数 a，导致中位寿命缩短，而时间参数B降低。逆 参数之间的相关性表示Strehler-Mildvan（S-M）关系， 其中低活力个体的丧失产生了具有较慢年龄依赖死亡率的队列 加速度类固醇激素拮抗剂米非司酮/RU 486逆转了这些作用。 交配和米非司酮在不同基因型和饮食中表现出强大的S-M关系， 限制显示了跨饮食的稳健的S-M关系。因为营养最佳值不同 在女性和男性之间，同样的操作对死亡率产生了相反的影响。 在不同营养浓度范围内，女性与男性的比率。同样，p53 果蝇中的mTOR突变和小鼠中的mTOR突变导致中位寿命延长 与女性死亡率参数的相反方向变化相关， 男性。数据表明，饮食和遗传干预具有性别特异性， 有时性对死亡率的相反影响与性对抗一致 多效性
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for several published studies. In Drosophila females, mating increases egg production and decreases median life span, consistent with a trade-off between reproduction and longevity. Mating increased parameter a, causing decreased median life span, whereas time parameter b was decreased. The inverse correlation between parameters indicates the Strehler–Mildvan (S-M) relationship, where loss of low-vitality individuals yields a cohort with slower age-dependent mortality acceleration. The steroid hormone antagonist mifepristone/RU486 reversed these effects. Mating and mifepristone showed robust S-M relationships across genotypes, and dietary restriction showed robust S-M relationship across diets. Because nutrient optima differed between females and males, the same manipulation caused opposite effects on mortality rates in females versus males across a range of nutrient concentrations. Similarly, p53 mutation in Drosophila and mTOR mutation in mice caused increased median life span associated with opposite direction changes in mortality rate parameters in females versus males. The data demonstrate that dietary and genetic interventions have sex-specific and sometimes sexually opposite effects on mortality rates consistent with sexual antagonistic pleiotropy.