Regulation of human hair growth by steroid hormones. II. Androstenedione metabolism in isolated hairs.
Regulation of human hair growth by steroid hormones. II. Androstenedione metabolism in isolated hairs.
复制标题
类固醇激素对人类毛发生长的调节。
DOI：
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发表时间：
1974
影响因子：
5.8
通讯作者：
Jean D. Wilson
中科院分区：
文献类型：
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作者：
Hans U. Schweikert;Jean D. Wilson
为探讨雄激素与毛发生长的关系，在标准化条件下，对4名女性和14名男性(其中6名男性有不同程度的男性型秃顶)的10个解剖部位的生长期和静止期的毛根进行了睾酮-1，2-3 H代谢的测定。建立了一种只在少数毛根中定量雄激素代谢的微量方法。在所有被检测的毛发中，5种α-还原和17-酮类固醇是睾酮的主要代谢物。雄激素介导的头发生长与5种α代谢物的形成能力之间没有明显的关系，例如，女性的头发进行5-α还原的程度与男性胡须的大致相同。所有部位的端原毛发中17-酮代谢产物的形成减少，而双氢睾酮的形成仅在头皮的端原毛发中减少。总体而言，5种α还原代谢物和17-酮类固醇代谢物在皮肤的各个部位都有较高的生成量。
ABSTRACT To investigate the relation between androgens and hair growth, testosterone-1,2-3H metabolism was assessed under standardized conditions in growing (anagen) and resting (telogen) hair roots from 10 anatomical sites from 4 women and 14 men, 6 of whom had varying degrees of male pattern baldness. A micromethod was developed to quantitate androgen metabolism in only a few hair roots. In all hairs examined, 5α-reduced and 17-ketosteroids were the major metabolites of testosterone. No significant relation was found between androgen-mediated growth of hair and the capacity to form 5α-metabolites, e.g., scalp hair of women performed 5α-reduction to approximately the same degree as beard hair from men. The formation of 17-ketometabolites was decreased in telogen hairs from all body sites, whereas the formation of dihydrotestosterone was decreased in telogen hairs only from the scalp. In general a higher formation of 5α-reduced metabolites and 17-ketosteroid metabolites was observed at all sites of the sc...