AKT1 (E17K) mutation in pancreatic cancer
AKT1 (E17K) mutation in pancreatic cancer
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DOI：
10.1177/153303460800700509
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发表时间：
2008-10-01
影响因子：
2.8
通讯作者：
Kocher, Hemant M.
中科院分区：
文献类型：
--
作者：
Mohamedali, Azim;Lea, Nicholas C.;Kocher, Hemant M.
使用定量焦磷酸测序测定在胰腺癌中研究了 AKT1 pleckstrin 同源结构域中新型体细胞突变 (E17K) 的流行情况。在胰腺癌组织样本 (n=65) 和胰腺细胞系 (n=10) DNA 中未检测到该突变，表明胰腺癌进展主要依赖于 K-Ras 突变。
The prevalence of a novel somatic mutation (E17K) in the pleckstrin homology domain of AKT1 was investigated in pancreatic cancer using a quantitative pyrosequencing assay. This mutation was un-detectable in pancreatic cancer tissue samples (n=65) and pancreatic cell line (n=10) DNA suggesting that pancreatic cancer progression is mainly dependent on the K-Ras mutation.