Variability in ultrasonic measurements of arterial stiffness in the atherosclerosis risk in communities study
Variability in ultrasonic measurements of arterial stiffness in the atherosclerosis risk in communities study
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DOI：
10.1016/s0301-5629(98)00165-3
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发表时间：
1999-02-01
影响因子：
2.9
通讯作者：
Riley, W
中科院分区：
文献类型：
--
作者：
Arnett, DK;Chambless, LE;Riley, W
动脉僵硬度正在成为心血管疾病的一个重要风险标志。几项大型流行病学研究正在使用基于超声的动脉硬度测量。作为其中一项研究的一部分，动脉粥样硬化风险（ARIC）研究评估了超声测量动脉硬度的可靠性。ARIC是一项前瞻性的四中心流行病学研究，使用B型超声和电子跟踪装置来测量颈动脉的动脉硬度。在动脉壁跟踪之前和之后获得示波血压测量。在36名志愿者中估计测量变异性，这些志愿者在7至14天间隔进行的三次访视中进行扫描。人与人之间和人与人之间的变异分量估计为动脉直径和血压测量。重复测量的脉压、动脉直径（应变）的百分比变化以及动脉面积的百分比和绝对变化之间的相关性（R）分别为0.69、0.67、0.66和0.81。应力-应变弹性模量（Ep）、动脉扩张性和动脉顺应性的R分别为0.66、0.67和0.77。压力调节直径变化的R（即，经舒张压和脉压调整的直径变化）为0.75。总之，ARIC研究中采用的动脉硬度的超声测量显示出优异的短期可重复性，证明了其在现场设置中的实用性。(C)1999年世界医学和生物学超声联合会。
Arterial stiffness is emerging as an important risk marker for cardiovascular disease. Ultrasound-based measurements of arterial stiffness are in use by several large epidemiological studies. The reliability of ultrasonic measurements of arterial stiffness was assessed as part of one of these, the Atherosclerosis Risk in communities (ARIC) study. ARIC, a prospective, four-center epidemiological study, used B-mode ultrasound with an electronic tracking device to measure arterial stiffness of the carotid artery. Oscillometric blood pressure measures were obtained before and after the arterial wall tracking. Measurement variability was estimated in 36 volunteers who were scanned at three visits conducted at 7- to 14-day intervals. Between- and within-person components of variation were estimated for arterial diameter and blood-pressure measurements. The correlation (R) between repeated measurements for pulse pressure, the percent change In arterial diameter (strain), and the percent and absolute change in the arterial area: were 0.69, 0.67, 0.66 and 0.81, respectively. The R for the stress-strain elastic modulus (Ep), arterial distensibility, and arterial compliance were 0.66, 0.67, and 0.77, respectively. The R for the pressure-adjusted diameter change (i.e., diameter change adjusted for diastolic and pulse pressures) was 0.75, In summary, the ultrasonic measurements of arterial stiffness employed in the ARIC study demonstrate excellent short-term repeatability, demonstrating their utility in field settings. (C) 1999 World Federation for Ultrasound in Medicine & Biology.