Expression and Function of Toll Pathway Components in the Early Development of the Wasp Nasonia vitripennis.
Expression and Function of Toll Pathway Components in the Early Development of the Wasp Nasonia vitripennis.
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DOI：
10.3390/jdb10010007
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发表时间：
2022-01-26
影响因子：
2.7
通讯作者：
Lynch JA
中科院分区：
文献类型：
--
作者：
Pers D;Buchta T;Özüak O;Roth S;Lynch JA
Toll信号通路是果蝇胚胎DV极性的主要来源。该途径似乎已经从昆虫内的祖先先天免疫系统中被增选，并且已经在昆虫分类群中以不同的方式被部署。本文报道了D.黑腹蜂Toll通路的研究进展。我们发现了所有成分的同源物;许多成分在黄蜂相对于苍蝇中有一个或多个额外的旁系同源物。我们还发现了N.丽翅凤蝶最后，我们提供了一些初步的功能分析的N。我们发现了一个功能保守和分歧的混合体。
The Toll signaling pathway is the main source of embryonic DV polarity in the fly Drosophila melanogaster. This pathway appears to have been co-opted from an ancestral innate immunity system within the insects and has been deployed in different ways among insect taxa. Here we report the expression and function of homologs of the important components of the D. melanogaster Toll pathway in the wasp Nasonia vitripennis. We found homologs for all the components; many components had one or more additional paralogs in the wasp relative the fly. We also found significant deviations in expression patterns of N. vitripennis homologs. Finally, we provide some preliminary functional analyses of the N. vitripennis homologs, where we find a mixture of conservation and divergence of function.