A pilot study on effects of 4×1 high-definition tDCS on motor cortex excitability.
A pilot study on effects of 4×1 high-definition tDCS on motor cortex excitability.
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DOI：
10.1109/embc.2012.6346036
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wassermann EM
中科院分区：
文献类型：
--
作者：
Caparelli-Daquer EM;Zimmermann TJ;Mooshagian E;Parra LC;Rice JK;Datta A;Bikson M;Wassermann EM
使用专用小电极的高清晰度经颅直流电刺激（HD-tDCS）已被提议作为一种局部、非侵入性神经调节技术。在这里，我们提供了第一个证据的变化后，HD-tDCS的运动皮层皮层的皮质兴奋性，使用TMS运动诱发电位（MEP）作为兴奋性的措施。与假刺激相比，以1 mA电流刺激20分钟，阳极位于运动皮层手部区域的中心，周围有4个返回电极（阳极4×1导联），刺激后MEP振幅和变异性显著增加。所有受试者对刺激耐受良好，不良反应仅限于电极下的短暂感觉。高分辨率计算模型证实了与传统tDCS相比，使用4×1 HD tDCS蒙太奇的聚焦性增加的预测。模拟还表明，中心电极相对于目标位置（中央沟）的位置变化可以解释增加的变化。这些结果为在需要病灶tDCS的情况下谨慎使用该技术提供了支持。
High-Definition transcranial Direct Current Stimulation (HD-tDCS) using specialized small electrodes has been proposed as a focal, non-invasive neuromodulatory technique. Here we provide the first evidence of a change in cortical excitability after HD-tDCS of the motor cortex, using TMS motor evoked potential (MEP) as the measure of excitability. Stimulation for 20 minutes at 1 mA with an anode centered over the hand area of the motor cortex and four surrounding return electrodes (anodal 4×1 montage) produced a significant increase in MEP amplitude and variability after stimulation, compared to sham stimulation. Stimulation was well tolerated by all subjects with adverse effects limited to transient sensation under the electrodes. A high-resolution computational model confirmed predictions of increased focality using the 4×1 HD tDCS montage compared to conventional tDCS. Simulations also indicated that variability in placement of the center electrode relative to the location of the target (central sulcus) could account for increasing variability. These results provide support for the careful use of this technique where focal tDCS is desired.