Retromer
Retromer
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DOI：
10.1016/j.ceb.2008.03.009
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发表时间：
2008-08-01
影响因子：
7.5
通讯作者：
Hurley, James H.
中科院分区：
文献类型：
--
作者：
Bonifacino, Juan S.;Hurley, James H.
逆转录聚合物是一种异五聚体复合物，其与内体的胞质面相关联，并介导跨膜货物从内体到高尔基体网络的逆行转运。哺乳动物逆转录聚合物复合物包含由SNX 1、SNX 2、SNX 5和SNX 6的仍未定义的组合组成的分选连接蛋白二聚体，以及由Vps 26、Vps 29和Vps 35组成的货物识别三聚体。SNX亚基含有PX和BAR结构域，其允许结合到内体囊泡和小管的PI（3）P富集的高度弯曲的膜，而Vps 26、Vps 29和Vps 35分别具有抑制蛋白、磷酸酯酶和α-螺线管折叠。最近的研究表明，retromer参与了广泛的生理、发育和病理过程，强调了由这种复合物介导的逆行转运的关键性质。
The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition trimer composed of Vps26, Vps29 and Vps35. The SNX subunits contain PX and BAR domains that allow binding to PI(3)P enriched, highly curved membranes of endosomal vesicles and tubules, while Vps26, Vps29 and Vps35 have arrestin, phosphoesterase and alpha-solenoid folds, respectively. Recent studies have implicated retromer in a broad range of physiological, developmental and pathological processes, underscoring the critical nature of retrograde transport mediated by this complex.