Chemical reaction powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals
Chemical reaction powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals
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化学反应驱动的瞬态聚合物水凝胶用于药物晶体的受控形成和自由释放
DOI：
10.1016/j.cej.2021.128877
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发表时间：
2021-06
影响因子：
15.1
通讯作者：
Wang Yiming
中科院分区：
文献类型：
--
作者：
Bai Shengyu;Niu Xiaofeng;Wang Hucheng;Wei Lai;Liu Liqun;Liu Xinyu;Eelkema Rienk;Guo Xuhong;van Esch Jan H.;Wang Yiming
非平衡态暂态材料由于其在热力学稳定场合很少观察到的独特性质而引起了极大的兴趣。然而，目前的进展仍然局限于超分子物体，并且利用这种瞬态性质的应用在很大程度上仍未被探索。在此，我们报告了化学燃料驱动的瞬态聚合物水凝胶，用于控制药物晶体的形成和自由释放。采用化学燃料交联技术制备了具有高度可调刚度和寿命的瞬态聚合物水凝胶，该聚合物水凝胶可以很好地再生，且只需加注燃料就不会出现明显的劣化。基于这些特性，特别是瞬态性质，这些水凝胶可以作为一种新的可重复使用的平台来控制药物结晶，更重要的是，可以自由释放所获得的晶体，这是传统静态凝胶无法实现的。这项工作有望成为加速开发更先进的非平衡材料和开发其高科技应用的一个范例。
Transient materials that function out-of-equilibrium have been of great interest due to their unique properties that are rarely observed in thermodynamically stable occasions. However, the current advances are still limited to supramolecular objects, and the applications using this transient nature remain largely unexplored. Herein we report on chemical fuel powered transient polymer hydrogels for controlled formation and free release of pharmaceutical crystals. The transient polymer hydrogels with highly tunable stiffness and lifetime were created by chemical fuel powered crosslinking, which can be well regenerated without obvious deteriorations by simply refueling. On the basis of these properties, especially the transient nature, these hydrogels can serve as novel reusable platforms to control the pharmaceutical crystallization, more importantly, freely release the obtained crystals, which is inaccessible by conventional static gels. This work is expected to serve as an example to accelerate the development of more advanced out-of-equilibrium materials and exploitations of their high-tech applications.
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影响因子：
16.6
作者：
Groetsch, Raphael K.;Angi, Arzu;Boekhoven, Job
通讯作者：
Boekhoven, Job
影响因子：
15
作者：
van Ravensteijn, Bas G. P.;Hendriksen, Wouter E.;Kegel, Willem K.
通讯作者：
Kegel, Willem K.
影响因子：
16.6
作者：
Tena-Solsona M;Rieß B;Grötsch RK;Löhrer FC;Wanzke C;Käsdorf B;Bausch AR;Müller-Buschbaum P;Lieleg O;Boekhoven J
通讯作者：
Boekhoven J
影响因子：
15
作者：
Sawczyk, Michal;Klajn, Rafal
通讯作者：
Klajn, Rafal
影响因子：
64.8
作者：
Sun, Jeong-Yun;Zhao, Xuanhe;Illeperuma, Widusha R. K.;Chaudhuri, Ovijit;Oh, Kyu Hwan;Mooney, David J.;Vlassak, Joost J.;Suo, Zhigang
通讯作者：
Suo, Zhigang