Behavioural and psychological symptoms of early-onset and late-onset Alzheimer's disease among Chinese adults: analysis of modifiable factors
Behavioural and psychological symptoms of early-onset and late-onset Alzheimer's disease among Chinese adults: analysis of modifiable factors
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DOI：
10.1111/psyg.12829
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发表时间：
2022-03-28
期刊：
影响因子：
2
通讯作者：
Sun, Jiao
中科院分区：
文献类型：
--
作者：
Fang, Shuyan;Zhang, Shuang;Sun, Jiao
目的比较早发性阿尔茨海默病（EOAD）和晚发性阿尔茨海默病（LOAD）患者痴呆的行为和心理症状（BPSD），并分析其差异因素。方法2018年11月至2019年5月，对中国93例EOAD和100例LOAD及其照顾者进行横断面调查。结果LOAD组神经精神量表总分显著高于对照组。EOAD中较高水平的激越与照顾者较低的生活质量和忽视痴呆患者的情绪表达有关。LOAD中较高的欣快评分与照顾者的消极应对减少以及家庭稳定性和可预测性降低有关。结论家属和医务人员对EOAD和LOAD的特异性BPSD进行早期识别和处理，可提高痴呆患者和照顾者的护理质量和生活质量。
Background To conduct a comprehensive comparison of behavioural and psychological symptoms of dementia (BPSD) in Chinese people with early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) and analyse the factors of differences. Methods A cross-sectional survey of 93 EOAD and100 LOAD and their caregivers in China from November 2018 to May 2019. Results The total Neuropsychiatric Inventory score was significantly higher in LOAD. A higher level of agitation in EOAD was related to a lower quality of life of caregivers and the emotional expression of ignoring people with dementia. Higher euphoria scores in LOAD were associated with reduced negative coping by caregivers and reduced stability and predictability at home. Conclusion The early identification and management of specific BPSD of EOAD and LOAD by family members and health professionals may improve the quality of care and life for people with dementia and that of caregivers.