Obesity: the protein leverage hypothesis
Obesity: the protein leverage hypothesis
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DOI：
10.1111/j.1467-789x.2005.00178.x
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发表时间：
2005-05-01
期刊：
影响因子：
8.9
通讯作者：
Raubenheimer, D
中科院分区：
文献类型：
--
作者：
Simpson, SJ;Raubenheimer, D
肥胖流行病是现代世界面临的最大公共卫生挑战之一。关于饮食原因，最重要的是改变脂肪和碳水化合物的消费模式。相比之下，蛋白质的作用在很大程度上被忽视了，因为(I)蛋白质通常只占饮食能量的15%，(Ii)在肥胖症流行的整个发展过程中，人群内部和人群之间的蛋白质摄入量几乎保持不变。我们证明，矛盾的是，正是这两种条件可能为蛋白质提供了杠杆，既可以通过影响食物摄入量来推动肥胖症流行，也可能缓解肥胖。我们用一个数学模型来形式化这个假设。提供了一些支持流行病学、实验和动物数据，并对未来的测试做出了预测。
The obesity epidemic is among the greatest public health challenges facing the modern world. Regarding dietary causes, most emphasis has been on changing patterns of fat and carbohydrate consumption. In contrast, the role of protein has largely been ignored, because (i) it typically comprises only similar to 15% of dietary energy, and (ii) protein intake has remained near constant within and across populations throughout the development of the obesity epidemic. We show that, paradoxically, these are precisely the two conditions that potentially provide protein with the leverage both to drive the obesity epidemic through its effects on food intake, and perhaps to assuage it. We formalize this hypothesis in a mathematical model. Some supporting epidemiological, experimental and animal data are presented, and predictions are made for future testing.