The role of androgen in the regulation of programmed cell death/apoptosis in normal and malignant prostatic tissue.
The role of androgen in the regulation of programmed cell death/apoptosis in normal and malignant prostatic tissue.
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DOI：
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发表时间：
1994-10
影响因子：
14.5
通讯作者：
J. Isaacs;Y. Furuya;R. Berges
中科院分区：
文献类型：
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作者：
J. Isaacs;Y. Furuya;R. Berges
细胞在其表观遗传程序库中具有经历细胞自杀过程的能力，称为程序性细胞死亡。这种程序性细胞死亡过程涉及细胞的表观遗传重编程，导致细胞内能量依赖性的生化和形态变化级联反应（也称为细胞凋亡），从而导致其死亡和消除。虽然最后的步骤（即DNA和细胞片段化）对于经历程序性死亡的细胞是常见的，但是该死亡过程的激活是通过由各种外源性损伤剂（例如辐射、化学品、病毒等）诱导的对细胞的充分损伤或通过一系列内源性信号（例如激素和生长/存活因子）水平的变化来启动的。作为一个说明性的例子，雄激素的作用作为一个细胞类型特异性内源性调节正常和肿瘤前列腺细胞的程序性死亡。
Cells possess within their repertoire of epigenetic programs the ability to undergo a process of cellular suicide, termed programmed cell death. This programmed cell death process involves an epigenetic reprogramming of the cell that results in an energy-dependent cascade of biochemical and morphologic changes within the cell (also termed apoptosis), resulting in its death and elimination. Although the final steps (i.e. DNA and cellular fragmentation) are common to cells undergoing programmed death, the activation of this death process is initiated either by sufficient injury to the cell induced by various exogenous damaging agents (e.g. radiation, chemicals, viruses, etc) or by changes in the levels of a series of endogenous signals (e.g. hormones and growth/survival factors). As an illustrative example, the role of androgen as a cell type specific endogenous regulator of the programmed death of normal and neoplastic prostatic cells will be presented.