Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges.
Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges.
复制标题
DOI：
10.4103/1477-3163.93001
复制
发表时间：
2012
影响因子：
--
通讯作者：
Vishwanatha JK
中科院分区：
文献类型：
--
作者：
Dasgupta S;Srinidhi S;Vishwanatha JK
前列腺癌是美国男性死亡的主要原因，目前早期诊断和适当治疗仍然是患者护理的关键方法。前列腺癌细胞携带多种分子扰动，产生恶性表型，能够不受控制的生长，存活和侵袭转移到其他器官。这些改变是通过肿瘤细胞中的遗传和表观遗传变化获得的，导致生长因子受体、信号蛋白、激酶、转录因子和辅助调节因子以及疾病进展所需的多种蛋白酶的激活。最近的进展提供了新的见解，这些致癌激活剂的分子功能，涉及潜在的治疗靶向治疗前列腺癌的机会。
Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic changes in tumor cells resulting in the activation of growth factor receptors, signaling proteins, kinases, transcription factors and coregulators, and multiple proteases required for the progression of the disease. Recent advances provide novel insights into the molecular functions of these oncogenic activators, implicating potential therapeutic targeting opportunities for the treatment of prostate cancer.