Olfactory function in workers exposed to styrene in the reinforced-plastics industry
Olfactory function in workers exposed to styrene in the reinforced-plastics industry
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DOI：
10.1002/ajim.10102
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发表时间：
2003-07-01
影响因子：
3.5
通讯作者：
Emmett, E
中科院分区：
文献类型：
--
作者：
Dalton, P;Cowart, B;Emmett, E
人类嗅觉功能的损害与职业性暴露于挥发性化学物质有关。为了调查苯乙烯暴露是否与嗅觉损伤有关，对塑料行业中至少接触苯乙烯4年的工人进行了嗅觉功能检查（当前平均暴露量：26 ppm，范围：10-60 ppm;历史平均剂量：156 ppm-年，范围：13.8-328 ppm-年）和一组年龄和性别匹配的未暴露的controls.Methods嗅觉功能进行了评估，使用标准化的电池，其中包括测试的阈值敏感度苯乙醇（PEA），气味识别能力，和鼻后气味感知。苯乙烯的气味检测阈值也得到了作为一个具体的适应工作环境的措施。结果无显着差异，观察暴露工人和对照组的嗅觉功能测试。暴露工人之间的苯乙烯气味检测阈值的升高表明，安全性引起的adaptation.Conclusions本研究发现，没有证据表明，目前或历史暴露于苯乙烯与嗅觉功能受损的一个横截面的塑料行业工人。结合啮齿动物和人类气道之间的解剖学差异以及缺乏人类鼻组织中苯乙烯代谢的证据，结果强烈表明，在这些浓度下，苯乙烯对人类不是嗅觉毒物。(C)2003 Wiley-Liss，Inc.
Background Impairment of olfactory function in humans has been associated with occupational exposure to volatile chemicals. To investigate whether exposure to styrene was associated with olfactory impairment, olfactory function was examined in workers with a minimum of 4 years exposure to styrene in the reinforced-plastics industry (current mean exposure: 26 ppm, range: 10-60 ppm; historic mean dose: 156 ppm-years, range: 13.8-328 ppm-years) and in a group of age- and gender-matched, unexposed controls.Methods Olfactory function was assessed using a standardized battery that included tests of threshold sensitivity for phenylethyl alcohol (PEA), odor identification ability, and retronasal odor perception. Odor detection thresholds for styrene were also obtained as a measure of specific adaptation to the work environment.Results No differences were observed between exposed workers and controls on tests Of olfactory function. Elevation of styrene odor detection thresholds among exposed workers indicated exposure-induced adaptation.Conclusions The present study found no evidence among a cross-section of reinforced-plastics industry workers that current or historical exposure to styrene was associated with impairment of olfactory function. Taken together with anatomical differences between rodent and human airways and the lack of evidence for styrene metabolism in human nasal tissue, the results strongly suggest that at these concentrations, styrene is not an olfactory toxicant in humans. (C) 2003 Wiley-Liss, Inc.