Bluetongue virus VP4 is an RNA-capping assembly line
Bluetongue virus VP4 is an RNA-capping assembly line
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DOI：
10.1038/nsmb1225
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发表时间：
2007-05-01
影响因子：
16.8
通讯作者：
Roy, Polly
中科院分区：
文献类型：
--
作者：
Sutton, Geoff;Grimes, Jonathan M.;Roy, Polly
真核生物通过一系列的四个化学反应来限制其信使RNA的5‘端。一些病毒使用单个分子实现这一点；蓝舌病毒这种酶的晶体结构揭示了一个细长的模块化结构，它为一组活性位点提供了支架，其中两个由新结构的结构域贡献。
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.