Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH
Radiotherapy for rectal cancer is associated with reduced serum testosterone and increased FSH and LH
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DOI：
10.1016/j.ijrobp.2007.10.043
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发表时间：
2008-03-01
影响因子：
7
通讯作者：
Guren, Marianne G.
中科院分区：
文献类型：
--
作者：
Bruheim, Kjersti;Svartberg, Johan;Guren, Marianne G.
目的：众所周知，盆腔放疗期间对睾丸的分散辐射会影响生育能力，但对其对男性性激素的影响知之甚少。本研究的目的是确定直肠癌放疗是否影响睾酮的产生。方法和材料：从挪威直肠癌登记处确定了 1993 年至 2003 年接受直肠癌辅助放疗的所有男性患者。仅接受手术治疗的患者是从同一登记处随机选择的作为对照受试者。分析卵泡刺激素（FSH）、黄体生成素（LH）、睾酮和性激素结合球蛋白（SHBG）的血清水平，并计算游离睾酮（N = 290）。从患者医院图表中收集有关放疗治疗的信息。结果：放疗组的血清 FSH 比对照组高 3 倍（中位数为 18.8 vs. 6.3 IU/L，p
Purpose: It is known that scattered radiation to the testes during pelvic radiotherapy can affect fertility, but there is little knowledge on its effects on male sex hormones. The aim of this study was to determine whether radiotherapy for rectal cancer affects testosterone production.Methods and Materials: All male patients who had received adjuvant radiotherapy for rectal cancer from 1993 to 2003 were identified from the Norwegian Rectal Cancer Registry. Patients treated with surgery alone were randomly selected from the same registry as control subjects. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and sex hormone binding globulin (SHBG) were analyzed, and free testosterone was calculated (N = 290). Information about the radiotherapy treatment was collected from the patient hospital charts.Results: Serum FSH was 3 times higher in the radiotherapy group than in the control group (median, 18.8 vs. 6.3 IU/L, p