Familial density of alcoholism and onset of adolescent drinking
Familial density of alcoholism and onset of adolescent drinking
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DOI：
10.15288/jsa.1999.60.7
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Yuan, HX
中科院分区：
文献类型：
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作者：
Hill, SY;Yuan, HX
目的：采用纵向前瞻性设计，本研究的目的是：(1)使用生存分析评估开始饮酒的年龄与酗酒家族史的关系；(2)使用Cox比例风险模型分析检查选定的危险因素在预测结果中的重要性。方法：对52例低酒精中毒风险儿童青少年和73例来自高危家庭的儿童青少年进行研究。研究对象年龄在7岁至18岁之间，每年进行一次评估（共268次评估），提供了2.1波关于发病年龄的纵向数据以及一些预测因子（酗酒阳性家族负荷、外向性和明显焦虑得分）。结果：高危儿童开始饮酒的年龄明显较早。Cox比例风险分析显示，酒精中毒和外向性的阳性家族负荷可以预测发病。进一步分析表明，外向性是家族密度效应的中介。结论：一般人群研究表明，开始饮酒的年龄可以预测出现酒精/滥用/依赖问题的可能性。进一步的随访将确定这些高危儿童是否比对照组儿童有更高的酒精滥用/依赖率。进一步的随访也将建立早期儿童预测因素之间的联系，比如性格外向和酗酒问题的发展。
Objective: Utilizing a longitudinal prospective design, the purpose of this study was to: (I) assess the age of onset to begin drinking in relation to family history of alcoholism using survival analysis, and (2) examine the importance of selected risk factors in predicting outcome, using a Cox proportional hazards model analysis. Method: Fifty-two children and adolescents at low risk for developing alcoholism and 73 children and adolescents from high-risk families were studied. Subjects, spanning the ages of 7 to 18, were evaluated annually (268 total evaluations), providing 2.1 waves of longitudinal data concerning age of onset along with a number of predictors (positive familial loading of alcoholism, extraversion, and manifest anxiety scores). Results: High-risk children showed a significantly earlier age of onset to begin drinking. The Cox proportional hazards analysis revealed that the onset could be predicted by a positive familial loading of alcoholism and extraversion. Further analyses revealed that extraversion was a mediator of the familial density effect. Conclusions: Age of onset to begin drinking has been shown in general population studies to predict the likelihood of developing alcohol/abuse/dependence problems. Further follow-up will determine if these high-risk children develop alcohol abuse/dependence at higher rates than control children. Further follow-up would also establish links between early childhood predictors, such as having an extraverted temperament and development of alcohol problems.