Insulin pump therapy with automated insulin suspension in response to hypoglycemia: reduction in nocturnal hypoglycemia in those at greatest risk.
Insulin pump therapy with automated insulin suspension in response to hypoglycemia: reduction in nocturnal hypoglycemia in those at greatest risk.
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DOI：
10.2337/dc10-2411
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发表时间：
2011-09
期刊：
影响因子：
16.2
通讯作者：
Amiel SA
中科院分区：
文献类型：
--
作者：
Choudhary P;Shin J;Wang Y;Evans ML;Hammond PJ;Kerr D;Shaw JA;Pickup JC;Amiel SA
评价具有低血糖暂停（LGS）功能的探头增强胰岛素泵，该功能可在探头检测到低血糖时自动暂停基础胰岛素输注长达2小时。Paradigm Veo胰岛素泵（Medtronic，Inc.，Northridge，CA）在31名1型糖尿病成人中进行了为期3周的测试。有166次LGS发作：66%的日间LGS发作在10 min内终止，20次发作持续最长2 h。在基线时夜间低血糖最高四分位数的患者中，LGS使用与夜间持续时间缩短≤2.2 mmol/L相关（中位46.2 vs. 1.8 min/d，P = 0.02 [LGS-关闭vs. LGS-开启]）。2小时LGS后的中位探头葡萄糖为3.9 mmol/L，基础重新开始后2小时为8.2 mmol/L。在最高风险人群中，使用胰岛素泵和LGS与降低夜间低血糖相关，并被患者广泛接受。
To evaluate a sensor-augmented insulin pump with a low glucose suspend (LGS) feature that automatically suspends basal insulin delivery for up to 2 h in response to sensor-detected hypoglycemia. The LGS feature of the Paradigm Veo insulin pump (Medtronic, Inc., Northridge, CA) was tested for 3 weeks in 31 adults with type 1 diabetes. There were 166 episodes of LGS: 66% of daytime LGS episodes were terminated within 10 min, and 20 episodes lasted the maximum 2 h. LGS use was associated with reduced nocturnal duration ≤2.2 mmol/L in those in the highest quartile of nocturnal hypoglycemia at baseline (median 46.2 vs. 1.8 min/day, P = 0.02 [LGS-OFF vs. LGS-ON]). Median sensor glucose was 3.9 mmol/L after 2-h LGS and 8.2 mmol/L at 2 h after basal restart. Use of an insulin pump with LGS was associated with reduced nocturnal hypoglycemia in those at greatest risk and was well accepted by patients.
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