Contrast enhancement of speckle patterns from blood in synchrotron X-ray imaging
Contrast enhancement of speckle patterns from blood in synchrotron X-ray imaging
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DOI：
10.1016/j.jbiomech.2008.11.037
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发表时间：
2009-03-11
影响因子：
2.4
通讯作者：
Lee, Sang Joon
中科院分区：
文献类型：
--
作者：
Kim, Guk Bae;Lee, Sang Joon
血流动力学已成为了解和诊断各种血管疾病的一个非常重要的因素。最近，X射线粒子图像测速（X射线PIV）方法使用散斑图案的血液已被引入作为一种新的定量可视化方法的血液流动没有任何播种示踪剂或造影剂。本研究对血液在同步辐射X射线成像方法上的特殊光学特性进行了深入、系统的研究。X射线PIV应用所需的实验条件是样品与闪烁体之间的距离（类似于40 cm）、血液样品的增稠（> 0.3min）和红细胞压积（20.0-80.0%）。此外，我们验证了X射线PIV方法是可靠的，作为一种先进的流动测速技术，通过比较从X射线PIV结果和注射泵提供的输入流量的误差小于1%的流量评估。通过本研究，在了解血液散斑图对比度增强机理的基础上，建立了一种可靠的血流可视化方法，可有效地应用于血流动力学研究。(c)2008爱思唯尔有限公司保留所有权利。
Hemodynamics has been a very important factor in understanding and diagnosing various vascular diseases. Recently, the X-ray particle image velocimetry (X-ray PIV) method using speckle patterns of blood has been introduced as a new quantitative visualization method for blood flows without any seeding tracer or contrast agents. In this study, the peculiar optical characteristics of blood on the synchrotron X-ray imaging method, which were not presented in previous studies, were investigated in depth and systematically. The experimental conditions required for X-ray PIV application were found to be the distance between the sample and the scintillator (similar to 40cm), the thickening of the blood sample (> 0.3 min), and hematocrit (20.0-80.0%). In addition, we verified that the X-ray PIV method is reliable as an advanced flow velocimetry by comparing the flow rate evaluated from the X-ray PIV result and the input flow rate supplied from a syringe pump with an error of less than 1%. Through this study, based on the understanding of contrast enhancement mechanisms of speckle patterns from blood, we Could establish a trustworthy flow visualization method that can be used effectively in hemodynamic studies. (c) 2008 Elsevier Ltd. All rights reserved.