Predicting the Prognosis of Oral Tongue Carcinoma Using a Simple Quantitative Measurement Based on Preoperative MR Imaging: Tumor Thickness versus Tumor Volume
Predicting the Prognosis of Oral Tongue Carcinoma Using a Simple Quantitative Measurement Based on Preoperative MR Imaging: Tumor Thickness versus Tumor Volume
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DOI：
10.3174/ajnr.a4278
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发表时间：
2015-07-01
影响因子：
3.5
通讯作者：
Shen, C. -Y.
中科院分区：
文献类型：
--
作者：
Hu, H.;Cheng, K. -L.;Shen, C. -Y.
背景和目的：多项研究表明，肿瘤厚度或肿瘤体积可能有助于预测口腔舌鳞状细胞癌的预后。我们的目的是比较肿瘤厚度与肿瘤体积测量术前磁共振成像的基础上预测口腔舌鳞状细胞癌的预后价值，特别是集中在淋巴结转移和局部recombination.MATERIALS和METHODS：临床，病理和影像学资料的患者46口腔舌鳞状细胞癌进行了回顾性研究。采用Logistic回归分析评价MRI上肿瘤厚度和肿瘤体积的预后价值。受试者操作特征分析应用于最佳的临界值为确定的风险变量预后。结果：一个较高的组内相关系数实现肿瘤厚度的测量相比，肿瘤体积（0.990比0.972）。多变量分析显示肿瘤厚度是淋巴结转移的重要预测因子（P = 0.024），而肿瘤体积不是淋巴结转移或局部复发的重要预测因子（P > 0.05）。受试者操作特征分析结果表明，以肿瘤厚度8.5mm为界值，对淋巴结转移的预测具有最佳诊断效率（曲线下面积，0.753;灵敏度，0.889;特异性，0.536）。术前MRI测量肿瘤厚度对判断舌鳞癌的预后，尤其是淋巴结转移，在我们的患者群体中，而肿瘤体积不是。
BACKGROUND AND PURPOSE: Several studies indicated that tumor thickness or tumor volume might be helpful predictors for the prognosis of oral tongue squamous cell carcinoma. Our aim was to compare the value of tumor thickness versus tumor volume measurement based on preoperative MR imaging in predicting the prognosis of oral tongue squamous cell carcinoma, especially focusing on lymph node metastases and local recurrence.MATERIALS AND METHODS: Clinical, pathologic, and imaging data of patients with 46 oral tongue squamous cell carcinomas were retrospectively studied. Logistic regression analysis was used to evaluate the prognostic value of tumor thickness and tumor volume based on MR imaging. Receiver operating characteristic analysis was applied for the optimal cutoff value for the identified risk variable for prognosis.RESULTS: A higher intraclass correlation coefficient was achieved for the measurement of tumor thickness compared with tumor volume (0.990 versus 0.972). Multivariate analysis showed that tumor thickness was a significant predictor of lymph node metastases (P = .024), while tumor volume was not a significant predictor of either lymph node metastases or local recurrence (P > .05). Receiver operating characteristic results indicated that setting a tumor thickness of 8.5 mm as a cutoff value could achieve the optimal diagnostic efficiency for predicting lymph node metastases (area under the curve, 0.753; sensitivity, 0.889; specificity, 0.536).CONCLUSIONS: Tumor thickness based on preoperative MR imaging was useful in predicting the prognosis of oral tongue squamous cell carcinoma, especially lymph node metastases, in our patient population, while tumor volume was not.