SYNCHRONOUS NEURAL AFTER DISCHARGES IN RAT HIPPOCAMPAL SLICES WITHOUT ACTIVE-CHEMICAL SYNAPSES
SYNCHRONOUS NEURAL AFTER DISCHARGES IN RAT HIPPOCAMPAL SLICES WITHOUT ACTIVE-CHEMICAL SYNAPSES
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DOI：
10.1126/science.7134978
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
DUDEK, FE
中科院分区：
文献类型：
--
作者：
TAYLOR, CP;DUDEK, FE
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Extracellular field potential and intracellular recordings from neurons in rat hippocampus show that, even with synaptic transmission blocked, antidromic electrical stimuli can trigger afterdischarges of .ltoreq. 9 s duration; during these discharges action potentials of a single neuron were synchronized with extracellularly recorded population spikes. Apparently mechanisms other than recurrent chemical synapses can synchronize and recruit epileptiform events. Measurements of transmembrane potential indicate that transient extracellular electrical fields (ephaptic interactions) contribute to the observed synchrony; electrotonic coupling and changes in the concentration of extracellular ions may also contribute.