Clinicopathologic similarities between Mikulicz disease and Kuttner tumor
Clinicopathologic similarities between Mikulicz disease and Kuttner tumor
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DOI：
10.1016/j.amjoto.2009.08.002
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发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Himi, Tetsuo
中科院分区：
文献类型：
--
作者：
Takano, Ken-ichi;Yamamoto, Motohisa;Himi, Tetsuo
目的：最近的研究表明，Mikulicz病（MD）不同于干燥综合征，是一种与免疫球蛋白G(4) （IgG(4)）相关的全身性疾病。库特纳瘤（KT）也是一种IgG(4)相关疾病。在这项研究中，我们检查了MD（39例）和KT（6例）的临床病理和血清学结果，并试图辨别MD和KT之间的相似之处。材料与方法：对39例MD和6例KT进行诊断。我们分析了39例MD患者和6例KT患者的临床病理和血清学结果（IgG亚类）。MD和KT患者的颌下腺和唇唾液腺标本进行抗igg(4)抗体染色。结果：MD患者IgG4平均浓度（+/- SD）为931.1 +/- 796.2 mg/dL， KT患者为756.2 +/- 449.2 mg/dL。在MD和KT患者中均观察到大量IgG(4)阳性浆细胞浸润到唾液腺中。结论：MD和KT的血清学和组织病理学表现非常相似，可能是IgG(4)相关的全身性疾病。(C) 2010爱思唯尔公司版权所有。
Purpose: Recent studies have revealed that Mikulicz disease (MD) differs from Sjogren syndrome and is an immunoglobulin G(4) (IgG(4)) related systemic disease. Kuttner tumor (KT) is also reported to be an IgG(4)-related disease. In this study, we examined the clinicopathologic and serologic findings in MD (39 patients) and KT (6 patients) and attempted to discern the similarities between MD and KT.Materials and methods: We diagnosed 39 patients with MD and 6 patients with KT. We analyzed the clinicopathologic and serologic findings (IgG subclasses) in 39 patients with MD and 6 patients with KT. Submandibular and labial salivary gland specimens obtained from patients with MD and KT were stained with anti-IgG(4) antibodies.Results: The mean IgG4 concentration (+/- SD) was 931.1 +/- 796.2 mg/dL in patients with MD and 756.2 +/- 449.2 mg/dL in patients with KT. Abundant infiltration of IgG(4)-positive plasmacytes into the salivary glands was observed in both patients with MD and patients with KT.Conclusion: The serologic and histopathologic findings in MD and KT are very similar, and these 2 conditions may be IgG(4)-related systemic diseases. (C) 2010 Elsevier Inc. All rights reserved.