Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.
Imaging Brown Adipose Tissue with TSPO PET Tracers in Preclinical Animal Studies.
复制标题
在临床前动物研究中使用 TSPO PET 示踪剂对棕色脂肪组织进行成像。
DOI：
10.1007/978-1-0716-3167-6_13
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Ran,Chongzhao
中科院分区：
文献类型：
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作者：
Zhu,Biyue;Liang,StevenH;Ran,Chongzhao
棕色脂肪组织(BAT)与产热密切相关，与多种疾病相关，包括2型糖尿病、非酒精性脂肪性肝病(NAFLD)和肥胖症。使用分子成像技术监测BAT有助于病因学的阐明、疾病的诊断和治疗的发展。转位蛋白(Translocator Protein，TSPO)是一种主要位于线粒体膜外的18kDa蛋白质，已被证明是监测蝙蝠体重的一种有前途的生物标志物。在这里，我们列出了在小鼠研究中使用TSPO PET示踪剂[18F]-DPA对BAT进行成像的步骤。
Brown adipose tissue (BAT) is closely associated with thermogenesis and related to numerous diseases, including type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), and obesity. Using molecular imaging technologies to monitor BAT could facilitate etiology elucidation, disease diagnosis, and therapeutics development. Translocator protein (TSPO), an 18 kDa protein that mainly locates on the outer mitochondrial membrane, has been proven as a promising biomarker for monitoring BAT mass. Here, we lay out the steps for imaging BAT with TSPO PET tracer [18F]-DPA in mouse studies.