Prevalence of Actinobacillus pleuropneumoniae serovars in England and Wales.
Prevalence of Actinobacillus pleuropneumoniae serovars in England and Wales.
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DOI：
10.1136/vr.c5106
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发表时间：
2010-10-23
期刊：
影响因子：
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通讯作者：
Langford PR
中科院分区：
文献类型：
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作者：
O'Neill C;Jones SC;Bossé JT;Watson CM;Williamson SM;Rycroft AN;Kroll JS;Hartley HM;Langford PR
胸膜肺炎放线杆菌是猪胸膜肺炎的病原体，猪胸膜肺炎是一种在世界范围内具有重要经济意义的猪地方性细菌性疾病（Bossé等，2002年）。流行病学上，血清分型是金标准方法，胸膜肺炎放线菌根据表面碳水化合物（主要是荚膜）的存在分为16个不同的血清型（1至4、5a、5b、6至15）。不同血清型的流行率因国家而异（Dubreuil等人，2000年）。传统上，分离物的血清型是使用从动物（通常是兔）获得的多克隆血清免疫学地确定的，所述动物已经用相关血清型的参考菌株的杀死的全细胞免疫。这种基于免疫学的方法具有局限性，特别是血清型之间的交叉反应性。已报告血清型1、9和11之间存在交叉反应性，
Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, an economically important endemic bacterial disease of pigs worldwide (Bossé and others 2002). Epidemiologically, serotyping is the gold standard method, with A pleuropneumoniae being classified into 16 different serovars (1 to 4, 5a, 5b, 6 to 15) based on the presence of surface carbohydrates, principally of the capsule. The prevalence of different serovars varies from country to country (Dubreuil and others 2000). Classically, the serovar of an isolate is determined immunologically using polyclonal serum obtained from animals (typically rabbits) that have been immunised with killed whole cells of a reference strain of the relevant serovar. Such immunological-based methods have limitations, in particular, crossreactivity between serovars. Cross-reactivity has been reported between serovars 1, 9 and 11,