Nicotine reduces antisaccade errors in task impaired schizophrenic subjects.
Nicotine reduces antisaccade errors in task impaired schizophrenic subjects.
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尼古丁可以减少任务受损的精神分裂症受试者的抗眼跳错误。
DOI：
10.1016/j.pnpbp.2004.01.002
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Sereno,AnneB
中科院分区：
文献类型：
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作者：
Larrison-Faucher,AbigailL;Matorin,AnuA;Sereno,AnneB
尼古丁和/或吸烟已被证明可以减少与精神分裂症相关的各种认知缺陷。在这里，我们研究了尼古丁口香糖对一个简单的眼动任务的重复性能的影响。8名精神分裂症患者和8名对照者参加了为期3天的眼跳（S）和反眼跳（AS）任务测试。在每个测试日，受试者参加四个测试阶段，并接受两种尼古丁口香糖治疗（4和6 mg）和两种对照条件（安慰剂口香糖和无口香糖），每个测试阶段之后都有一个恢复期。总体而言，精神分裂症患者在AS任务上表现出显着的障碍。然而，在个别检查时，只有四个精神分裂症患者表现出显着差异，在AS错误或反应时间（RT）相比，控制。其他四名精神分裂症患者表现出控制水平的表现。所有的精神分裂症受试者表现出正常和优于控制水平的性能上的简单的S任务。此外，尼古丁对简单S任务没有影响。对AS任务有显著的治疗效果。尼古丁治疗显着减少错误的任务受损的精神分裂症组，这种效果是最明显的6毫克水平。未受损的精神分裂症受试者或对照组未显示尼古丁效应。这项研究表明，短期接触尼古丁对认知受损的精神分裂症受试者有好处。这些结果支持了先前关于尼古丁对精神分裂症患者认知益处的发现。
Nicotine and/or smoking have been shown to reduce various cognitive deficits associated with schizophrenia. Here, we examine the effects of nicotine gum on repeated performance on a simple eye movement task. Eight schizophrenic subjects and eight controls participated in three days of testing on saccade (S) and antisaccade (AS) tasks. On each testing day, subjects participated in four testing sessions and received both of two nicotine gum treatments (4 and 6 mg) and both of two control conditions (placebo gum and no gum), each followed by a recovery period. Overall, schizophrenics showed significant impairments on the AS task. However, upon individual examination only four schizophrenics showed significant differences in AS errors or reaction times (RTs) when compared to controls. The other four schizophrenic subjects showed control level performance. All schizophrenic subjects showed normal and better than control level performance on the simple S task. Furthermore, no effects of nicotine were seen on the simple S task. There were significant treatment effects on the AS task. Nicotine treatment significantly decreased errors in the task impaired schizophrenic group and this effect was most pronounced at the 6 mg level. No nicotine effects were demonstrated for non-impaired schizophrenic subjects or controls. This study demonstrates a benefit of short exposure to nicotine in cognitively impaired schizophrenic subjects. These results support previous findings of cognitive benefits of nicotine in schizophrenics.