CELLULAR IMMUNE-RESPONSES DURING COMPLICATED AND UNCOMPLICATED MEASLES-VIRUS INFECTIONS OF MAN
CELLULAR IMMUNE-RESPONSES DURING COMPLICATED AND UNCOMPLICATED MEASLES-VIRUS INFECTIONS OF MAN
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DOI：
10.1016/0090-1229(84)90184-3
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发表时间：
1984-01-01
期刊：
影响因子：
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通讯作者：
VAISBERG, A
中科院分区：
文献类型：
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作者：
HIRSCH, RL;GRIFFIN, DE;VAISBERG, A
麻疹患者的淋巴细胞对有丝分裂原的增殖反应表现出深刻而持久的抑制。无并发症的麻疹病毒感染患者与肺炎或感染后脑炎患者的抑制程度相似。尽管有这种抑制作用，但在脑炎患者和无并发症的疾病中，甚至在感染早期，淋巴细胞对麻疹抗原和PPD（纯化蛋白衍生物）的反应也被证实。大多数肺炎患者没有明显的抗原特异性反应。T辅助细胞（OKT4）和T抑制细胞（okt8）的比例以及Con A[豆豆蛋白A]抑制细胞活性的功能测试显示，对照组和麻疹患者之间没有显著差异，但与对照组相比，在没有任何兴奋剂的情况下培养的麻疹患者细胞显著抑制异体反应细胞的增殖。这些培养的20个上清液中有9个具有可溶性抑制因子。这些研究表明麻疹期间免疫反应性的各种破坏。
Lymphocytes from patients with measles showed profound and prolonged suppression of proliferative responses to mitogens. The degree of suppression was similar in patients with uncomplicated measles virus infection and in those with pneumonia or postinfectious encephalitis. Despite this suppression, lymphocyte responses to measles antigen and PPD [purified protein derivative] were demonstrated in patients with encephalitis and uncomplicated disease, even early in infection. Most patients with pneumonia did not have demonstrable antigen-specific responses. The proportions of T helper (OKT4) and T suppressor (OKT 8) cells and functional tests of Con A [concanavalin A] suppressor cell activity showed no significant difference between control and measles patients but, in contrast to controls, cells from measles patients cultured in the absence of any stimulant significantly suppressed the proliferation of allogeneic responder cells. Nine of 20 supernatant fluids from these cultures possessed a soluble suppressor factor. These studies indicate varied disruptions of immune reactivity during measles.