Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice
Effects of the non-competitive NMDA receptor antagonist ifenprodil on the morphine-induced place preference in mice
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DOI：
10.1016/s0024-3205(99)00036-3
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发表时间：
1999-02-12
期刊：
影响因子：
6.1
通讯作者：
Misawa, M
中科院分区：
文献类型：
--
作者：
Suzuki, T;Kato, H;Misawa, M
观察了非竞争性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂艾芬地尔对吗啡诱导的小鼠位置偏爱的影响。吗啡（1-5 mg/kg，s.c.）在小鼠中产生了剂量相关的位置偏好。相比之下，单独的艾芬地尔（5-20 mg/kg，i. p.）对与毒品有关的地方没有产生偏好或厌恶。用艾芬地尔（5-20 mg/kg，i. p.）以剂量依赖的方式抑制吗啡产生的位置偏爱。这些结果表明，艾芬地尔抑制吗啡产生的奖励效应。(C)1999 Elsevier Science Inc.
The effects of ifenprodil, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on the morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.) produced a dose-related place preference in mice. In contrast, ifenprodil alone (5-20 mg/kg, i.p.) did not produce either preference or aversion for the drug-associated place. Pretreatment with ifenprodil (5-20 mg/kg, i.p.) suppressed the place preference produced by morphine in a dose-dependent manner. These results indicate that ifenprodil suppresses the rewarding effect produced by morphine. (C) 1999 Elsevier Science Inc.