Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment.
Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment.
复制标题
结直肠癌中 mRNA 的选择性剪接：肿瘤诊断和治疗的新策略。
DOI：
10.1038/s41419-021-04031-w
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发表时间：
2021-07-30
影响因子：
9
通讯作者：
Chu X
中科院分区：
文献类型：
--
作者：
Chen Y;Huang M;Liu X;Huang Y;Liu C;Zhu J;Fu G;Lei Z;Chu X
替代剪接（AS）是有助于转录后基因调控的重要事件。这个过程导致具有多种生理功能的几种成熟的转录物变体。实际上，这种多步过程的各个方面的破坏（例如顺式或转移因子改变）促进了结直肠癌的进展。因此，针对某些特定过程的AS可能是治疗癌症的有效治疗策略。在这里，我们根据过去5年的研究提供了与结直肠癌有关的AS事件的概述。我们专注于与恶性标志相关的变体产品的机制和功能，重点是具有临床意义的变体。此外，讨论了利用AS事件的治疗价值的新型策略。
Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature transcript variants with diverse physiological functions. Indeed, disruption of various aspects of this multistep process, such as cis- or trans- factor alteration, promotes the progression of colorectal cancer. Therefore, targeting some specific processes of AS may be an effective therapeutic strategy for treating cancer. Here, we provide an overview of the AS events related to colorectal cancer based on research done in the past 5 years. We focus on the mechanisms and functions of variant products of AS that are relevant to malignant hallmarks, with an emphasis on variants with clinical significance. In addition, novel strategies for exploiting the therapeutic value of AS events are discussed.
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影响因子：
12.3
作者：
Akerman M;Fregoso OI;Das S;Ruse C;Jensen MA;Pappin DJ;Zhang MQ;Krainer AR
通讯作者：
Krainer AR
影响因子：
3.4
作者：
Rangwala, Fatima;Bendell, Johanna C.;Kozloff, Mark F.;Arrowood, Christy C.;Dellinger, Andrew;Meadows, Jennifer;Tourt-Uhlig, Sandra;Murphy, Jennifer;Meadows, Kellen L.;Starr, Aijing;Broderick, Samuel;Brady, John C.;Cushman, Stephanie M.;Morse, Michael A.;Uronis, Hope E.;Hsu, S. David;Zafar, S. Yousuf;Wallace, James;Starodub, Alexander N.;Strickler, John H.;Pang, Herbert;Nixon, Andrew B.;Hurwitz, Herbert I.
通讯作者：
Hurwitz, Herbert I.
影响因子：
5.4
作者：
Bruun GH;Doktor TK;Borch-Jensen J;Masuda A;Krainer AR;Ohno K;Andresen BS
通讯作者：
Andresen BS
影响因子：
64.8
作者：
Bertram, Karl;Agafonov, Dmitry E.;Luehrmann, Reinhard
通讯作者：
Luehrmann, Reinhard
影响因子：
4.8
作者：
Chen, Yi-Tung;Chang, Ian Yi-Feng;Tan, Bertrand Chin-Ming
通讯作者：
Tan, Bertrand Chin-Ming