High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport
High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport
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DOI：
10.1016/0021-9150(96)05852-2
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发表时间：
1996-07-01
期刊：
影响因子：
5.3
通讯作者：
Huang, YD
中科院分区：
文献类型：
--
作者：
Assmann, G;Schulte, H;Huang, YD
通过前瞻性心血管Munster（PROCAM）研究评估了19698例年龄在16至65岁之间的志愿受试者的冠心病（CHD）发病率。动脉粥样硬化性CHD的适当发病率仅见于40岁以上的男性受试者。因此，分析和随后的6年随访期仅限于4559名40-64岁的男性参与者。在随访期间，186名研究参与者发生了动脉粥样硬化性CHD（134例明确的非致命性心肌梗死（MI）和52例明确的动脉粥样硬化性CHD死亡，包括21例心脏性猝死和31例致命性MI）。单因素分析显示高密度脂蛋白胆固醇与冠心病发病率有显著相关性（P < 0.001），校正其他危险因素后仍有相关性。
The incidence of coronary heart disease (CHD) was assessed via the Prospective Cardiovascular Munster (PROCAM) study in 19 698 volunteer subjects aged between 16 and 65 years. An adequate incidence of atherosclerotic CHD was only found in male subjects greater than 40 years of age. The analysis and subsequent 6 year follow-up period was, therefore, confined to 4559 male participants aged 40-64 years. In the follow-up period, 186 study participants developed atherosclerotic CHD (134 definite non-fatal myocardial infarctions (MIs) and 52 definite atherosclerotic CHD deaths including 21 sudden cardiac deaths and 31 fatal MIs). Univariate analysis revealed a significant association between the incidence of atherosclerotic CHD and high-density lipoprotein cholesterol (P < 0.001), which remained after adjustment for other risk factors.