Consumption of dietary supplements and over-the-counter and prescription medications in men participating in the Prostate Cancer Prevention Trial at an academic center
Consumption of dietary supplements and over-the-counter and prescription medications in men participating in the Prostate Cancer Prevention Trial at an academic center
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DOI：
10.1016/j.urolonc.2007.01.016
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发表时间：
2008-03-01
影响因子：
2.7
通讯作者：
Clinton, Steven K.
中科院分区：
文献类型：
--
作者：
Grainger, Elizabeth M.;Kim, H. Sunny;Clinton, Steven K.
目的：假设饮食结构、个体营养素、特定处方和非处方药可能影响前列腺癌的发生。关于参与前列腺癌预防试验的男性使用这些产品的信息很少。材料和方法：在一个学术中心参加前列腺癌预防试验(PCPT)的92名男性(平均年龄69岁)被要求携带所有营养补充剂和药物进行定期研究访问。结果：收集了92名男性中的86人的数据。我们发现，在PCPT中，85%的男性经常至少摄入营养补充剂。每名男性平均(+/-标准差)的膳食补充剂消耗量为3.3+/-3.5(范围0-21)。复合维生素和多种矿物质补充剂(73%)是最常见的消费产品。经常食用的单一营养补充剂包括：维生素E(48%)、维生素C(31%)、钙(24%)和硒(7%)。在男性中，36%的人报告消费了草药产品。研究期间经常使用的可能影响前列腺癌发生的药物包括非类固醇抗炎药(57%)、降压药(49%)、降脂药(27%)和阿司匹林(%)。结论：某学术中心PCPT的参与者有较高的饮食补充剂使用倾向。许多物质，如维生素E和硒，被认为会影响前列腺癌的风险。几种常用的药物，包括阿司匹林、非类固醇抗炎药和他汀类药物，正在作为化学预防药物进行研究。设计前列腺癌化学预防试验的研究人员应考虑包括可能影响研究结果的暴露于这些产品的详细记录。(C)2008 Elsevier Inc.保留所有权利。
Objective: It is hypothesized that dietary patterns, individual nutrients, and specific prescription and over-the-counter medications may influence prostate carcinogenesis. Little information is available regarding the use of these products among men who are participating in prevention trials targeting prostate cancer.Materials and methods: A total of 92 men (mean age 69 years) participating in the Prostate Cancer Prevention Trial (PCPT) at an academic center were asked to bring all nutritional supplements and medications to regularly scheduled Study visits.Results: Data were collected on 86 of 92 men. We found that 85% of men in the PCPT regularly consumed at least I nutritional supplement. The mean (+/- standard deviation) number of dietary supplements consumed per man was 3.3 +/- 3.5 (range 0-21). A multivitamin and multimineral (73%) supplement was the most common product consumed. Single-nutrient supplements regularly consumed included: vitamin E (48%), vitamin C (31%), calcium (24%), and selenium (7%). Of men, 36% reported consumption of herbal products. Medications frequently consumed during the study period that may influence prostate carcinogenesis included nonsteroidal antiinflammatory drugs (57%), antihypertensives (49%), lipid lowering agents (27%), and aspirin (64%).Conclusions: Participants in the PCPT at an academic center have a high propensity for dietary Supplement use. Many, Such as vitamin E and selenium, are hypothesized to influence the risk of prostate cancer. Several of the medications commonly consumed, including aspirin, nonsteroidal antiinflammatory drugs, and statins, are being investigated as chemopreventive agents. Investigators designing prostate cancer chemoprevention trials should consider including detailed documentation of exposure to these products that may influence Study outcomes. (c) 2008 Elsevier Inc. All rights reserved.