A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses
A new clinical approach: Use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses
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DOI：
10.1016/j.lfs.2012.03.004
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发表时间：
2012-06-06
期刊：
影响因子：
6.1
通讯作者：
Gambacurta, A.
中科院分区：
文献类型：
--
作者：
Marfe, G.;Rotta, G.;Gambacurta, A.
目的：在本研究中，我们提出了一种利用干细胞治疗指屈肌腱(软)损伤的创新方法。主要方法：从三匹马的血液样本中分离出血源性干细胞，并在巨噬细胞集落刺激因子(M-CSF)的存在下进行培养。赛马接受了一次自体BDSC治疗，成功修复了肌腱损伤。关键发现：结果表明，BDSC注射到损伤的肌腱中刺激了正常组织的再生。此外，新组织形成的速度和质量与治疗动物的福利和管理之间可能存在关系。意义：这项研究表明，干细胞技术为许多情况下被认为是不可治愈的组织修复提供了新的工具，并提供了额外的证据，表明注射BDSCs可以提高不同动物组织中再生过程的速度和质量。(C)2012 Elsevier Inc.保留所有权利。
Aims: In this study, we present an innovative therapy using stem cells that superficial digital flexor tendon (SOFT) injuries.Main methods: Blood-derived stem cells (BDSCs) were generated from the blood samples of three horses in the presence of macrophage colony-stimulating factor (M-CSF). The racehorses received a single autologous BDSC treatment, which resulted in the successful repair of the tendons injuries.Key findings: The results demonstrated that the BDSCs injection into the damaged tendon stimulated the regeneration of normal tissue. Furthermore, a relationship may exist between the speed and the quality of new tissue formation and the welfare and management of the treated animals.Significance: This study demonstrates that stem cell technology offers new tools for tissue repair that in many cases is considered incurable, and provides additional evidence that BDScs injections increase the speed and quality of the regeneration process in different animal tissues. (C) 2012 Elsevier Inc. All rights reserved.