Codon usage in Tetrahymena and other ciliates.
Codon usage in Tetrahymena and other ciliates.
复制标题
四膜虫和其他纤毛虫中的密码子使用。
DOI：
10.1111/j.1550-7408.1989.tb02679.x
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Duane W. Martindale
中科院分区：
文献类型：
--
作者：
Duane W. Martindale
通过分析相当于 26,142 个核苷酸（8,714 个密码子）的 22 个纤毛虫基因的编码区，检查了纤毛虫的密码子使用情况。研究发现，四膜虫、草履虫和毛毛虫（尖毛虫和柱甲虫）的不同之处在于它们的基因最常使用同义密码子。事实上，高表达的四膜虫基因的密码子选择与酵母基因的密码子选择比草履虫基因的密码子选择更相似。与酵母等其他原生生物相比，纤毛虫在密码子使用频率方面似乎没有异常强烈的偏差。对四膜虫基因的分析表明，在正常细胞生长期间高表达的基因比在生长期间或在接合等过程的短暂时期内以较低水平表达的基因更倾向于使用“优选”密码子。这与在其他原生生物中发现的情况一致。
Codon usage in ciliates was examined by analyzing the coding regions of 22 ciliate genes corresponding to a total of 26,142 nucleotides (8,714 codons). It was found that Tetrahymena, Paramecium and the hypotrichs (Oxytricha and Stylonychia) differed in which synonymous codons were used most frequently by their genes. In fact, the codon choices in highly expressed Tetrahymena genes were more similar to those of yeast genes than those of Paramecium genes. The ciliates do not appear to have unusually strong biases in codon usage frequency when compared to other protists such as yeast. The analysis of the Tetrahymena genes indicated that genes which are highly expressed during normal cell growth have a stronger bias towards using the "preferred" codons than those expressed at lower levels during growth or for brief periods during processes such as conjugation. This conforms to what is found in other protists.
DOI：
10.1111/j.1550-7408.1987.tb03205.x
发表时间：
1987
期刊：
The Journal of protozoology
影响因子：
--
作者：
PreerJr,JR;Preer,LB;Rudman,B;Barnett,A
通讯作者：
Barnett,A