Efficient Medium Ring Size Bromolactonization Using a Sulfur-Based Zwitterionic Organocatalyst
Efficient Medium Ring Size Bromolactonization Using a Sulfur-Based Zwitterionic Organocatalyst
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DOI：
10.1021/ja307210n
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发表时间：
2012-10-10
影响因子：
15
通讯作者：
Yeung, Ying-Yeung
中科院分区：
文献类型：
--
作者：
Cheng, Yi An;Chen, Tao;Yeung, Ying-Yeung
据报道，使用两性离子催化剂和化学计量的 N-溴代琥珀酰亚胺卤素源，长链烯酸的催化溴内酯化反应可有效合成中等尺寸的内酯。研究发现该反应在 0 摄氏度下比在室温下更有效，这可能归因于两性离子催化剂的温度依赖性。
Catalytic bromolactonization of long-chain olefinic acids resulting in the efficient synthesis of medium-sized lactones is reported using a zwitterionic catalyst and stoichiometric N-bromosuccinimide halogen source. The reaction was found to be more efficient at 0 degrees C than at room temperature, which could be attributed to the temperature dependence of the zwitterionic catalyst.