Safety Warning for ChAdOx1 nCov-19 Vaccine in Patients with Sickle Cell Disease.
Safety Warning for ChAdOx1 nCov-19 Vaccine in Patients with Sickle Cell Disease.
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DOI：
10.4084/mjhid.2021.059
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发表时间：
2021
影响因子：
3.2
通讯作者：
Pathare AV
中科院分区：
文献类型：
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作者：
Alkindi S;Elsadek RA;Pathare AV
针对急性呼吸综合征冠状病毒 2 (SARS-CoV2) 的疫苗是控制致命的冠状病毒 2019 (COVId-19) 病毒在全球范围内传播的关键武器。尽管这些疫苗通常是安全的，但它们的广泛使用产生了罕见并发症的报告，包括疫苗诱导的免疫性血栓性血小板减少症 (VIITT)，特别是与 ChAdOx1 nCov-19 相关的并发症。我们发现了三例镰状细胞病 (SCD) 病例，在接种疫苗后不久就出现了严重的血管闭塞危机 (VOC)。尽管病情稳定很长一段时间，他们还是发烧、心动过速，同时白细胞、肝酶（特别是碱性磷酸盐）显着升高，血红蛋白和血小板显着下降，其中一人可能患有致命的 TTP 样综合征。鉴于这些发现，医生和患者在服用此类疫苗时应谨慎行事，并注意这些安全问题。
Vaccines against acute respiratory syndrome Coronavirus 2(SARS-CoV2) are critical weapons to control the spread of the deadly Coronavirus 2019(COVId-19) virus worldwide. Although these vaccines are generally safe, their widespread use has produced reports of rare complications, including vaccine-induced immune thrombotic thrombocytopenia (VIITT), particularly in connection with ChAdOx1 nCov-19. We have identified three cases of sickle cell disease (SCD) experiencing a severe vaso-occlusive crisis (VOC) shortly after the vaccine. Despite being stable for a long time, they had fever with tachycardia, along with a significant rise in WBC, liver enzymes, particularly alkaline phosphate, with a remarkable drop in hemoglobin, and platelets and one of them had probably a fatal TTP like syndrome. Given these findings, physicians and patients should exercise caution when taking this type of vaccine and be aware of these safety concerns.