Chebulagic acid is a potent α-glucosidase inhibitor
Chebulagic acid is a potent α-glucosidase inhibitor
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DOI：
10.1271/bbb.70591
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发表时间：
2008-02-01
影响因子：
1.6
通讯作者：
Kawabata, Jun
中科院分区：
文献类型：
--
作者：
Gao, Hong;Huang, Yi-Na;Kawabata, Jun
从chebula Terminalia chebula Retz中分离得到的Chebulagic acid是一种可逆的、非竞争性的麦芽糖酶抑制剂，其K-i值为6.6 μ m。Chebulagic acid对麦芽糖酶-葡萄糖淀粉酶复合物的抑制作用强于对蔗糖酶-异麦芽糖酶复合物的抑制作用。chebulagic acid对α -葡萄糖苷酶的抑制程度受其来源的影响很大。这些结果显示了chebulagic酸在治疗2型糖尿病中的作用。
Chebulagic acid, isolated form Terminalia chebula Retz, proved to be a reversible and non-competitive inhibitor of maltase with a K-i value of 6.6 mu m. The inhibitory influence of chebulagic acid on the maltase-glucoamylase complex was more potent than on the sucrase-isomaltase complex. The magnitude of alpha-glucosidase inhibition by chebulagic acid was greatly affected by its origin. These results show a use for chebulagic acid in managing type-2 diabetes.