Multiple Hox/HOM-class homeoboxes in Platyhelminthes.
Multiple Hox/HOM-class homeoboxes in Platyhelminthes.
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扁形动物中有多个 Hox/HOM 类同源盒。
DOI：
10.1006/mpev.1993.1014
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发表时间：
1993
影响因子：
4.1
通讯作者：
Ruddle,FH
中科院分区：
文献类型：
--
作者：
Bartels,JL;Murtha,MT;Ruddle,FH
Hox/HOM类同源框基因在早期前后模式形成中的重要性以及该基因家族的保守基因组组织为基因组进化提供了有趣的研究。扁形动物（扁虫）是一种基础后生动物群，具有简单的双侧身体结构。我们使用聚合酶链反应 (PCR) 检测代表两类扁虫的物种中的 Hox/HOM 类同源盒基因。发现了 7 个涡虫和 5 个吸虫Hox/HOM 类同源框。基因序列与扁虫中 oneHox/HOM 型簇的存在一致。对这个假定簇的进一步分析有望为研究高等后生动物中Hox/HOM簇的进化提供外群信息。
The importance of theHox/HOMclass of homeobox genes in early anterior-posterior pattern formation and the conserved genomic organization of this gene family provides an interesting study in genome evolution. The Platyhelminthes (flatworms) are a basal metazoan group with a simple bilateral body plan. We used the polymerase chain reaction (PCR) to detectHox/HOM-class homeobox genes from species representing two classes of flatworms. Seven planarian and five trematodeHox/HOM-class homeoboxes were found. The sequences of the genes are consistent with the presence of oneHox/HOM-type cluster in the flatworms. Further analysis of this putative cluster may be expected to provide outgroup information for studying the evolution of theHox/HOMclusters in the higher metazoa.