Studies on the effect of thyroxine replacement therapy on the increased insulin response to hyperglycemia in the thyroidectomized dog.
Studies on the effect of thyroxine replacement therapy on the increased insulin response to hyperglycemia in the thyroidectomized dog.
复制标题
研究甲状腺素替代疗法对甲状腺切除犬高血糖胰岛素反应增强的影响。
DOI：
10.1055/s-0028-1094036
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Rodríguez Rr
中科院分区：
文献类型：
--
作者：
A. Renauld;Sverdlik Rc;Andrade Ll;Rodríguez Rr
Summary This in vivo study assessed the immediate effects of insulin on glucose and ketone body utilization in the fed, fasted, and diabetic ketoacidotic rat. The experimental design con sisted of the functional removal of the liver (the site of glu cose and ketone body production) and the pancreas from the anesthetized animals. This surgical procedure permitted the assessment of the effect of exogenously administered in sulin on the rate of both glucose and ketone body utiliza tion by peripheral tissues. Insulin exerted hypoglycemic activity in all three metabolic states studied. This hypoglycemic activity contrasted to the lack of demonstrable effect of this hormone on ketone bo dy uptake by peripheral tissues. It was conc\uded that in the rat, the immediate effect of insulin, i.e. within 30 minutes, was to exert hypoglycemic activity without simultaneous hy poketoniemic activity.
